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Details on Person UniProt:P35527 KRT9
| Class:Id | ReferenceGeneProduct:57695 |
|---|---|
| _chainChangeLog | chain:1-623 added on Fri February 6 2015 |
| _displayName | UniProt:P35527 KRT9 |
| _timestamp | 2024-11-03 19:36:58 |
| chain | chain:1-623 |
| checksum | 45C833749B63873D |
| comment | FUNCTION May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly.SUBUNIT Heterotetramer of two type I and two type II keratins.TISSUE SPECIFICITY Expressed in the terminally differentiated epidermis of palms and soles.INDUCTION Induced by intrinsic regulatory mechanisms and by extrinsic signals from a subset of dermal palmoplantar fibroblasts.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).SIMILARITY Belongs to the intermediate filament family.CAUTION Was originally thought to be a 60 kDa chain of placental scatter protein. |
| description | recommendedName: Keratin, type I cytoskeletal 9 alternativeName: Cytokeratin-9 shortName: CK-9 alternativeName: Keratin-9 shortName: K9 |
| geneName | KRT9 |
| identifier | P35527 |
| isSequenceChanged | FALSE |
| keyword | Coiled coil Direct protein sequencing Disease variant Intermediate filament Keratin Palmoplantar keratoderma Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | KRT9 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957791] ENSEMBL:ENSG00000171403 KRT9 [Homo sapiens] |
| secondaryIdentifier | K1C9_HUMAN O00109 Q0IJ47 Q14665 |
| sequenceLength | 623 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6809601] KRT9 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8957425] KRT9 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P35527 KRT9 (57695)
