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Details on Person UniProt:P18084 ITGB5
| Class:Id | ReferenceGeneProduct:57605 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-799 added on Fri February 6 2015 |
| _displayName | UniProt:P18084 ITGB5 |
| _timestamp | 2024-11-03 19:51:45 |
| chain | signal peptide:1-23 chain:24-799 |
| checksum | D7E4727CA310512B |
| comment | FUNCTION Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.FUNCTION (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.SUBUNIT Heterodimer of an alpha and a beta subunit. Beta-5 (ITGB5) associates with alpha-V (ITGAV). Interacts with MYO10 (PubMed:15156152). Interacts with DAB2. Integrin ITGAV:ITGB5 interacts with FBLN5 (via N-terminus) (By similarity). ITGAV:ITGB5 interacts with CCN3 (PubMed:15611078). Interacts with tensin TNS3; TNS3 also interacts with PEAK1, thus acting as an adapter molecule to bridge the association of PEAK1 with ITGB5 (PubMed:35687021).SUBUNIT (Microbial infection) Integrin ITGAV:ITGB5 interacts with adenovirus type C penton protein.INTERACTION The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.SIMILARITY Belongs to the integrin beta chain family. |
| description | recommendedName: Integrin beta-5 |
| geneName | ITGB5 |
| identifier | P18084 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Calcium Cell adhesion Cell membrane Disulfide bond EGF-like domain Glycoprotein Host cell receptor for virus entry Host-virus interaction Integrin Magnesium Membrane Metal-binding Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ITGB5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001835] ENSEMBL:ENSG00000082781 ITGB5 [Homo sapiens] |
| secondaryIdentifier | ITB5_HUMAN B0LPF8 B2RD70 |
| sequenceLength | 799 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:215948] ITGB5 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1236749] ITGB5 [phagocytic vesicle] [Homo sapiens] [EntityWithAccessionedSequence:9987555] ITGB5 [early endosome membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P18084 ITGB5 (57605)
