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Details on Person UniProt:P05107 ITGB2

Class:Id	ReferenceGeneProduct:57599
_chainChangeLog	signal peptide:1-22 added on Fri February 6 2015;chain:23-769 added on Fri February 6 2015
_displayName	UniProt:P05107 ITGB2
_timestamp	2026-02-20 23:06:45
chain	signal peptide:1-22 chain:23-769
checksum	0390BD89F1E71E98
comment	FUNCTION Integrin ITGAL:ITGB2 is a receptor for ICAM1, ICAM2 and ICAM3 (PubMed:1676048, PubMed:23775590, PubMed:38195629). Integrin ITGAL:ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM:ITGB2 and ITGAX:ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX:ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM:ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM:ITGB2 is also a receptor for factor X. Integrin ITGAD:ITGB2 is a receptor for ICAM3 and VCAM1 (PubMed:10438935, PubMed:8777714, PubMed:9841932). Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL:ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). Integrins ITGAX:ITGB2 functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis (PubMed:16985175). Integrins ITGAX:ITGB2 functions as a receptor of the neuron-specific adhesion molecule ICAM5 ensuring neuron cell-leukocyte adhesion (PubMed:10741396). Integrin ITGAL:ITGB2 functions as a receptor of ICAM1 by acting as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion (PubMed:38195629). Integrin ITGAM:ITGB2/MAC-1 complex functions as a signaling receptor for the ligand receptor ICAM1, ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124). Integrin ITGAL/ITGB2 that functions as a signaling receptor of ICAM2, ensuring leukocyte cell-cell adhesion on resting cells (PubMed:1676048).SUBUNIT Heterodimer of an alpha and a beta subunit (PubMed:20033057, PubMed:26936951). The ITGB2 beta subunit associates with the ITGAL, ITGAM, ITGAX or ITGAD alpha subunits (PubMed:20033057, PubMed:24385486, PubMed:26936951). Found in a complex with CD177 and ITGAM/CD11b (PubMed:21193407, PubMed:28807980). Interacts with FGR (By similarity). Interacts with COPS5 and RANBP9 (PubMed:10766246, PubMed:14722085). Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) (PubMed:19828450). Interacts with THBD (PubMed:27055590).INTERACTION Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980).DOMAIN The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.PTM Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters (PubMed:11700305). Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins (PubMed:11700305, PubMed:16301335).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the integrin beta chain family.ONLINE INFORMATION ITGB2 mutation db
description	recommendedName: fullName evidence="43"Integrin beta-2 alternativeName: Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta alternativeName: Complement receptor C3 subunit beta cdAntigenNameCD18/cdAntigenName
geneName	ITGB2 CD18 MFI7
identifier	P05107
isSequenceChanged	FALSE
keyword	3D-structure Calcium Cell adhesion Cell membrane Direct protein sequencing Disease variant Disulfide bond EGF-like domain Glycoprotein Integrin Magnesium Membrane Metal-binding Phagocytosis Phosphoprotein Proteomics identification Pyrrolidone carboxylic acid Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	ITGB2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:6789341] ENSEMBL:ENSG00000160255 ITGB2 [Homo sapiens]
secondaryIdentifier	ITB2_HUMAN B3KTS8 D3DSM1 Q16418 Q53HS5 Q9UD72
sequenceLength	769
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:198010] ITGB2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6803284] ITGB2 [specific granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6803310] ITGB2 [ficolin-1-rich granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6803342] ITGB2 [tertiary granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:9940525] ITGB2 (GC B cell) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9946335] ITGB2 (Tfh cell) [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P05107 ITGB2 (57599)