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Details on Person UniProt:P08514 ITGA2B

Class:Id	ReferenceGeneProduct:57579
_chainChangeLog	signal peptide:1-31 added on Sat February 7 2015;chain:32-1039 added on Sat February 7 2015;chain:32-887 added on Sat February 7 2015;chain:891-1039 added on Sat February 7 2015;chain:903-1039 added on Sat February 7 2015
_displayName	UniProt:P08514 ITGA2B
_timestamp	2026-02-20 22:55:49
chain	signal peptide:1-31 chain:32-1039 chain:32-887 chain:891-1039 chain:903-1039
checksum	063EE298E026F116
comment	FUNCTION Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity). Integrin ITGA2B:ITGB3 is also the receptor of erythrocyte-specific ICAM4 ligand involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets (PubMed:12477717).SUBUNIT Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. Interacts (via C-terminus cytoplasmic tail region) with CIB1; the interaction is direct and calcium-dependent. Interacts (via C-terminus cytoplasmic tail region) with CIB2, CIB3 and CIB4; the interactions are stabilized/increased in a calcium and magnesium-dependent manner. ITGA2B:ITGB3 interacts with PPIA/CYPA; the interaction is ROS and PPIase activity-dependent and is increased in the presence of thrombin (By similarity). ITGA2B:ITGB3 interacts with SELP (via C-type lectin domain); the interaction mediates cell-cell interaction and adhesion (PubMed:37184585).INTERACTION Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines (PubMed:2351656). Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level) (PubMed:9809974).PTM Cleaved by ELANE; the cleavage promotes activation of platelet fibrinogen receptor integrin alpha-IIb/beta-3.POLYMORPHISM Genetic variants in ITGA2B define different platelet-specific alloantigen systems that are involved in fetomaternal alloimmune thromobocytopenia. Alloantigen system Bak, also known as HPA-3 or Lek, is characterized by variant p.Ser874Ile (alloantigen Bak(a) or Lek(a) or HPA-3a) and variant p.Ile874Ser (alloantigen Bak(b) or Lek(b) or HPA-3b) (PubMed:2350579, PubMed:7197082, PubMed:14516468, PubMed:15569236). Additional platelet-specific alloantigens involved in fetomaternal alloimmune thromobocytopenia are known (PubMed:7620155, PubMed:19821948, PubMed:23305224).DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the integrin alpha chain family.
description	recommendedName: fullName evidence="60"Integrin alpha-IIb alternativeName: GPalpha IIb shortName evidence="58"GPIIb alternativeName: Platelet membrane glycoprotein IIb cdAntigenNameCD41/cdAntigenName component recommendedName: Integrin alpha-IIb heavy chain /component component recommendedName: Integrin alpha-IIb light chain, form 1 /component component recommendedName: Integrin alpha-IIb light chain, form 2 /component
geneName	ITGA2B GP2B ITGAB
identifier	P08514
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Calcium Cell adhesion Cell membrane Cleavage on pair of basic residues Direct protein sequencing Disease variant Disulfide bond Glycoprotein Integrin Membrane Metal-binding Proteomics identification Pyrrolidone carboxylic acid Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	ITGA2B
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8935736] ENSEMBL:ENSG00000005961 ITGA2B [Homo sapiens]
secondaryIdentifier	ITA2B_HUMAN B2RCY8 O95366 Q14443 Q17R67
sequenceLength	1039
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:148994] UniProt:P08514-2 ITGA2B [Homo sapiens] [ReferenceIsoform:148995] UniProt:P08514-3 ITGA2B [Homo sapiens] [ReferenceIsoform:402615] UniProt:P08514-1 ITGA2B [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:57578] ITGA2B(32-1039) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:114511] ITGA2B(32-?) [platelet alpha granule membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P08514 ITGA2B (57579)