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Details on Person UniProt:P53708 ITGA8
| Class:Id | ReferenceGeneProduct:57575 |
|---|---|
| _chainChangeLog | signal peptide:1-38 added on Sat February 7 2015;chain:39-1063 added on Sat February 7 2015;chain:39-906 added on Sat February 7 2015;chain:907-1063 added on Sat February 7 2015 |
| _displayName | UniProt:P53708 ITGA8 |
| _timestamp | 2024-11-03 20:19:37 |
| chain | signal peptide:1-38 chain:39-1063 chain:39-906 chain:907-1063 |
| checksum | 8F9614BDBB897D77 |
| comment | FUNCTION Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.SUBUNIT Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-8 associates with beta-1.SUBCELLULAR LOCATION Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the integrin alpha chain family. |
| description | recommendedName: Integrin alpha-8 component recommendedName: Integrin alpha-8 heavy chain /component component recommendedName: Integrin alpha-8 light chain /component |
| geneName | ITGA8 |
| identifier | P53708 |
| isSequenceChanged | FALSE |
| keyword | Calcium Cell adhesion Cell membrane Cleavage on pair of basic residues Developmental protein Differentiation Disease variant Disulfide bond Glycoprotein Integrin Membrane Metal-binding Neurogenesis Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ITGA8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996037] ENSEMBL:ENSG00000077943 ITGA8 [Homo sapiens] |
| secondaryIdentifier | ITA8_HUMAN B0YJ31 Q5VX94 |
| sequenceLength | 1063 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:215943] ITGA8(39-1063) [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P53708 ITGA8 (57575)
