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Details on Person UniProt:P08648 ITGA5

Class:IdReferenceGeneProduct:57569
_chainChangeLogsignal peptide:1-41 added on Fri February 6 2015;chain:42-1049 added on Fri February 6 2015;chain:42-894 added on Fri February 6 2015;chain:895-1049 added on Fri February 6 2015
_displayNameUniProt:P08648 ITGA5
_timestamp2025-02-21 20:10:32
chainsignal peptide:1-41
chain:42-1049
chain:42-894
chain:895-1049
checksum6B4D558D4F739CBA
commentFUNCTION Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).FUNCTION (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.FUNCTION (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.FUNCTION (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.SUBUNIT Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. ITGA5/Alpha-5 associates with ITGB1/beta-1 (PubMed:33962943). Interacts with NISCH (PubMed:11912194). Interacts with HPS5 (PubMed:10094488). Interacts with RAB21 and COMP. Interacts with CIB1. ITGA5:ITGB1 interacts with CCN3. ITGA5:ITGB1 interacts with FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 interacts with IL1B (PubMed:29030430). ITGA5:ITGB1 interacts with ACE2 (PubMed:33102950). ITGA5:ITGB1 interacts with SELP (PubMed:37184585). Interacts with ANGPT2 (PubMed:32908006). ITGA5:ITGB1 interacts with IGFBP2 (PubMed:16569642, PubMed:26076738). ITGA5:ITGB1 interacts with IGFBP1 (PubMed:7504269).SUBUNIT (Microbial infection) Integrin ITGA5:ITGB1 interacts with human metapneumovirus fusion protein.SUBUNIT (Microbial infection) Integrin ITGA5:ITGB1 interacts with human parvovirus B19 capsid proteins.SUBUNIT (Microbial infection) Interacts with HIV-1 Tat.SUBUNIT (Microbial infection) ITGA5:ITGB1 interacts with SARS coronavirus-2/SARS-CoV-2 spike protein.INTERACTION Expressed in placenta (at protein level).PTM Proteolytic cleavage by PCSK5 mediates activation of the precursor.SIMILARITY Belongs to the integrin alpha chain family.
descriptionrecommendedName: fullName evidence="31"Integrin alpha-5 alternativeName: CD49 antigen-like family member E alternativeName: Fibronectin receptor subunit alpha alternativeName: Integrin alpha-F alternativeName: VLA-5 cdAntigenNameCD49e/cdAntigenName component recommendedName: Integrin alpha-5 heavy chain /component component recommendedName: Integrin alpha-5 light chain /component
geneNameITGA5
FNRA
identifierP08648
isSequenceChangedFALSE
keyword3D-structure
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Integrin
Membrane
Metal-binding
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9841277] Weiser, Joel
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
nameITGA5
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8939662] ENSEMBL:ENSG00000161638 ITGA5 [Homo sapiens]
secondaryIdentifierITA5_HUMAN
Q96HA5
sequenceLength1049
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:202735] ITGA5(42-894) [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:8961328] ITGA5 [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:9857636] ITGA5 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:9857662] p-S-ITGA5 [plasma membrane] [Homo sapiens]
(referenceSequence)[ModifiedResidue:9857646] O-phospho-L-serine at unknown position
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No pathways have been reviewed or authored by UniProt:P08648 ITGA5 (57569)
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