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Details on Person UniProt:P14616 INSRR
| Class:Id | ReferenceGeneProduct:57525 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Fri February 6 2015;chain:27-1297 added on Fri February 6 2015;chain:27-742 added on Fri February 6 2015;chain:747-1297 added on Fri February 6 2015 |
| _displayName | UniProt:P14616 INSRR |
| _timestamp | 2025-02-21 18:37:34 |
| chain | signal peptide:1-26 chain:27-1297 chain:27-742 chain:747-1297 |
| checksum | BB22C7FF61E3065D |
| comment | FUNCTION Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)SUBUNIT Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.INTERACTION The extracellular domain is required for sensing alterations in external pH.PTM Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. |
| description | recommendedName: Insulin receptor-related protein shortName: IRR ecNumber: 2.7.10.1 alternativeName: IR-related receptor component recommendedName: Insulin receptor-related protein alpha chain /component component recommendedName: Insulin receptor-related protein beta chain /component |
| geneName | INSRR IRR |
| identifier | P14616 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Cleavage on pair of basic residues Disulfide bond Glycoprotein Kinase Membrane Nucleotide-binding Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Transferase Transmembrane Transmembrane helix Tyrosine-protein kinase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | INSRR |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990183] ENSEMBL:ENSG00000027644 INSRR [Homo sapiens] |
| secondaryIdentifier | INSRR_HUMAN O60724 Q5VZS3 |
| sequenceLength | 1297 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:211400] INSRR(27-1297) [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P14616 INSRR (57525)
