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Details on Person UniProt:Q9NPI9 KCNJ16
| Class:Id | ReferenceGeneProduct:57517 |
|---|---|
| _chainChangeLog | chain:1-418 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NPI9 KCNJ16 |
| _timestamp | 2025-02-21 18:47:51 |
| chain | chain:1-418 |
| checksum | 1E241B4C15CBD264 |
| comment | FUNCTION Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201).CATALYTIC ACTIVITY K(+)(in) = K(+)(out)ACTIVITY REGULATION Channel activity is strongly regulated by variations of cytosolic pH; channels are activated by alkaline and inhibited by acidic pH values. Activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2).SUBUNIT It forms heteromeric channels with Kir4.1/KCNJ10; this interaction is required for KCNJ16 localization to the basolateral membrane in kidney cells. As a heteromer with KCNJ10, may interact with MAGI1; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney cells (PubMed:24561201). May form heteromers with Kir2.1/KCNJ2 (Probable). Can form heteromeric channels with Kir4.2/KCNJ15 (By similarity).SUBCELLULAR LOCATION In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10.TISSUE SPECIFICITY Widely expressed, with highest levels in adult and fetal kidney (at protein level). In the kidney, expressed in the proximal and distal convoluted tubules, but not in glomeruli nor collecting ducts.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily. |
| description | recommendedName: Inward rectifier potassium channel 16 alternativeName: Inward rectifier K(+) channel Kir5.1 alternativeName: Potassium channel, inwardly rectifying subfamily J member 16 |
| geneName | KCNJ16 |
| identifier | Q9NPI9 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Deafness Disease variant Ion channel Ion transport Membrane Phosphoprotein Potassium Potassium transport Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport Voltage-gated channel |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | KCNJ16 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004186] ENSEMBL:ENSG00000153822 KCNJ16 [Homo sapiens] |
| secondaryIdentifier | KCJ16_HUMAN |
| sequenceLength | 418 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:975281] KCNJ16 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NPI9 KCNJ16 (57517)
