Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P00995 SPINK1
| Class:Id | ReferenceGeneProduct:57437 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Sat February 7 2015;chain:24-79 added on Sat February 7 2015 |
| _displayName | UniProt:P00995 SPINK1 |
| _timestamp | 2024-11-03 20:10:22 |
| chain | signal peptide:1-23 chain:24-79 |
| checksum | 3583C8196952EB3A |
| comment | FUNCTION Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:7142173). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity).FUNCTION In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.INTERACTION Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry. |
| description | recommendedName: fullName evidence="14"Serine protease inhibitor Kazal-type 1 alternativeName: fullName evidence="12"Pancreatic secretory trypsin inhibitor alternativeName: Tumor-associated trypsin inhibitor shortName: TATI |
| geneName | SPINK1 PSTI |
| identifier | P00995 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Disease variant Disulfide bond Protease inhibitor Proteomics identification Reference proteome Secreted Serine protease inhibitor Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SPINK1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001834] ENSEMBL:ENSG00000164266 SPINK1 [Homo sapiens] |
| secondaryIdentifier | ISK1_HUMAN |
| sequenceLength | 79 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8986409] SPINK1(29-41) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8986410] SPINK1(76-79) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8986413] SPINK1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8986414] SPINK1(42-67) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8986423] SPINK1(68-75) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8986424] SPINK1(24-28) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9922915] SPINK1 [zymogen granule] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P00995 SPINK1 (57437)
