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Details on Person UniProt:P01308 INS
Class:Id
ReferenceGeneProduct:57415
_chainChangeLog
signal peptide:1-24 added on Fri February 6 2015;peptide:25-54 added on Fri February 6 2015;propeptide:57-87 added on Fri February 6 2015;peptide:90-110 added on Fri February 6 2015
_displayName
UniProt:P01308 INS
_timestamp
2026-02-20 21:40:34
chain
signal peptide:1-24 peptide:25-54 propeptide:57-87 peptide:90-110
checksum
C2C3B23B85E520E5
comment
FUNCTION Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.SUBUNIT Heterodimer of a B chain and an A chain linked by two disulfide bonds (PubMed:25423173).INTERACTION Expressed by pancreatic beta-cells (at protein level).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.PHARMACEUTICAL Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.SIMILARITY Belongs to the insulin family.SEQUENCE CAUTION Protein of the 20th century - Issue 9 of April 2001ONLINE INFORMATION Insulin entry
description
recommendedName: Insulin component recommendedName: Insulin B chain /component component recommendedName: Insulin A chain /component
geneName
INS
identifier
P01308
isSequenceChanged
FALSE
keyword
3D-structure Alternative splicing Carbohydrate metabolism Cleavage on pair of basic residues Diabetes mellitus Direct protein sequencing Disease variant Disulfide bond Glucose metabolism Hormone Pharmaceutical Proteomics identification Reference proteome Secreted Signal
