Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person UniProt:P05014 IFNA4

Class:IdReferenceGeneProduct:57359
_chainChangeLogsignal peptide:1-23 added on Fri February 6 2015;chain:24-189 added on Fri February 6 2015
_displayNameUniProt:P05014 IFNA4
_timestamp2026-02-20 22:55:38
chainsignal peptide:1-23
chain:24-189
checksum828DF9C33ABC337F
commentFUNCTION Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.INTERACTION Two forms exist; alpha-4a (shown here) and alpha-4b (PubMed:9335434). They seem to be equally abundant (PubMed:9335434).SIMILARITY Belongs to the type-I (or alpha/beta) interferon family.
descriptionrecommendedName: Interferon alpha-4 shortName: IFN-alpha-4 alternativeName: Interferon alpha-4B alternativeName: Interferon alpha-76 alternativeName: Interferon alpha-M1
geneNameIFNA4
identifierP05014
isSequenceChangedFALSE
keywordAntiviral defense
Cytokine
Direct protein sequencing
Disulfide bond
Proteomics identification
Reference proteome
Secreted
Signal
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
nameIFNA4
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:9001206] ENSEMBL:ENSG00000236637 IFNA4 [Homo sapiens]
secondaryIdentifierIFNA4_HUMAN
P13358
Q14CS4
Q5VV15
sequenceLength189
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:877342] IFNA4 [extracellular region] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P05014 IFNA4 (57359)