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Details on Person UniProt:P01563 IFNA2
| Class:Id | ReferenceGeneProduct:57357 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-188 added on Fri February 6 2015 |
| _displayName | UniProt:P01563 IFNA2 |
| _timestamp | 2026-02-20 22:55:38 |
| chain | signal peptide:1-23 chain:24-188 |
| checksum | 9BAA221D2BFB421D |
| comment | FUNCTION Produced by macrophages, IFN-alpha have antiviral activities.SUBUNIT Interacts with IFNAR2.INTERACTION Three alleles exist; alpha-2A, alpha-2B (shown here) and alpha-2C (PubMed:7627809). Allele alpha-2B is the predominant allele while allele alpha-2A is less predominant and alpha-2C only a minor allelic variant.PHARMACEUTICAL Available under the names Roferon-A (Roche) or Intron-A (Schering-Plough). Used as an anticancer drug for its antiproliferative activity.SIMILARITY Belongs to the type-I (or alpha/beta) interferon family. |
| description | recommendedName: Interferon alpha-2 shortName: IFN-alpha-2 alternativeName: Interferon alpha-A shortName evidence="13"LeIF A |
| geneName | IFNA2 IFNA2A IFNA2B IFNA2C |
| identifier | P01563 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Antiviral defense Cytokine Direct protein sequencing Disulfide bond Glycoprotein Pharmaceutical Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | IFNA2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991320] ENSEMBL:ENSG00000188379 IFNA2 [Homo sapiens] |
| secondaryIdentifier | IFNA2_HUMAN H2DF54 H2DF55 P01564 Q14606 Q6DJX8 Q96KI6 |
| sequenceLength | 188 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:877349] IFNA2 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P01563 IFNA2 (57357)
