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Details on Person NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene

Class:Id	BlackBoxEvent:573376
_displayName	NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene
_doRelease	TRUE
_timestamp	2014-11-20 02:45:22
authored	[InstanceEdit:565730] May, B, 2010-04-06
catalystActivity	[CatalystActivity:573375] histone deacetylase activity of NoRC:pRNA:Hdac:Dnmt [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:573322] May, B, 2010-04-10
edited	[InstanceEdit:565730] May, B, 2010-04-06
input	[SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [Complex:573317] Nucleosome (H4K5ac, H4K8ac, H4K16ac) [nucleoplasm] [Mus musculus]
literatureReference	[LiteratureReference:427357] Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation [LiteratureReference:427396] The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription [LiteratureReference:427450] The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing [LiteratureReference:427384] The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription
modified	[InstanceEdit:580595] May, B, 2010-04-11 [InstanceEdit:2876561] May, B, 2012-12-23 [InstanceEdit:5219070] May, B, 2013-12-21 [InstanceEdit:5227039] May, B, 2014-01-09 [InstanceEdit:5250950] May, B, 2014-01-31 [InstanceEdit:5332992] May, B, 2014-02-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene
output	[SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:427486] CH3COO- [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:427486] CH3COO- [nucleoplasm] [SimpleEntity:427486] CH3COO- [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:427486] CH3COO- [nucleoplasm] [SimpleEntity:427486] CH3COO- [nucleoplasm] [SimpleEntity:427486] CH3COO- [nucleoplasm] [Complex:573397] Nucleosome (deacetylated H4, H3K9me2) [nucleoplasm] [Mus musculus]
precedingEvent	[Reaction:573336] Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene [Mus musculus] [Reaction:573369] Ttf1 binds the T0 region (Sal Box) of the rDNA [Mus musculus]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5332991] Shiao, YH, 2014-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:5644748] R-MMU-573376.2
summation	[Summation:580601] Histones in silenced rRNA gene copies are deacetylated by Hd...
(inferredFrom)	[BlackBoxEvent:433672] NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 [Homo sapiens]
(precedingEvent)	[Reaction:573383] NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes [Mus musculus]
(replacementInstances)	[_Deleted:9032440] Deletion of instance: 5334727 [_Deleted:9032446] Deletion of instance: 573389
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No pathways have been reviewed or authored by NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene (573376)