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Details on Person Ttf1 binds the T0 region (Sal Box) of the rDNA

Class:Id	Reaction:573369
_displayName	Ttf1 binds the T0 region (Sal Box) of the rDNA
_doRelease	TRUE
_timestamp	2026-05-06 19:06:31
authored	[InstanceEdit:565730] May, B, 2010-04-06
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:573322] May, B, 2010-04-10
edited	[InstanceEdit:565730] May, B, 2010-04-06
input	[EntityWithAccessionedSequence:573306] Ttf1 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:5096480] T0 region of rDNA [nucleoplasm] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:74988] Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I. [LiteratureReference:5211368] Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites [LiteratureReference:74990] A repeated 18 bp sequence motif in the mouse rDNA spacer mediates binding of a nuclear factor and transcription termination. [LiteratureReference:427458] Epigenetic regulation of TTF-I-mediated promoter-terminator interactions of rRNA genes [LiteratureReference:5219066] The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo
modified	[InstanceEdit:2876561] May, B, 2012-12-23 [InstanceEdit:5211378] May, B, 2013-12-10 [InstanceEdit:5219070] May, B, 2013-12-21 [InstanceEdit:5225701] May, B, 2014-01-08 [InstanceEdit:5250950] May, B, 2014-01-31 [InstanceEdit:5332992] May, B, 2014-02-18 [InstanceEdit:8856905] May, Bruce, 2016-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9988367] Rothfels, Karen, 2026-05-06
name	Ttf1 binds the T0 region (Sal Box) of the rDNA
output	[Complex:573309] Ttf-I:T0 region of rDNA [nucleoplasm] [Mus musculus]
precedingEvent	[BlackBoxEvent:573343] Cleavage of intergenic spacer RNA to yield fragments of 150-300 nucleotides [Mus musculus] [BlackBoxEvent:573384] Transcription of intergenic spacer of the rRNA gene [Mus musculus]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5332991] Shiao, YH, 2014-02-18 [InstanceEdit:8856904] Iben, Sebastian, 2016-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:5644240] R-MMU-573369.3
summation	[Summation:573327] The Transcription termination factor (Ttf1, also known as Tt...
(inferredFrom)	[Reaction:74987] TTF1 binds to the Sal Box [Homo sapiens] [Reaction:74994] Elongating RNA Polymerase I Transcription Complex pauses at the TTF1:Sal Box [Homo sapiens]
(precedingEvent)	[Reaction:573336] Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene [Mus musculus]
(replacementInstances)	[_Deleted:9032440] Deletion of instance: 5334727 [_Deleted:9032446] Deletion of instance: 573389
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