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Details on Person TRAF6 binding to IRAK2 stimulates its oligomerizartion upon TLR7 or TLR21 stimulation

Class:Id	Reaction:573297
_displayName	TRAF6 binding to IRAK2 stimulates its oligomerizartion upon TLR7 or TLR21 stimulation
_doRelease	TRUE
_timestamp	2011-03-02 09:13:45
authored	[InstanceEdit:1094913] Shamovsky, V, 2010-11-30
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:573295] Shamovsky, V, 2010-04-09
edited	[InstanceEdit:1221606] Shamovsky, V, 2011-02-24
inferredFrom	[Reaction:975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments [Homo sapiens]
input	[EntityWithAccessionedSequence:433792] TRAF6 [endosome membrane] [Gallus gallus] [EntityWithAccessionedSequence:433792] TRAF6 [endosome membrane] [Gallus gallus] [Complex:993986] TRAF6:p-IRAK2 [endosome membrane] [Gallus gallus]
literatureReference	[LiteratureReference:450115] TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB
modified	[InstanceEdit:434393] Shamovsky, V, 2009-08-28 [InstanceEdit:993985] Shamovsky, V, 2010-11-05 [InstanceEdit:1216499] Shamovsky, V, 2011-02-14 [InstanceEdit:1220566] Shamovsky, V, 2011-02-21 [InstanceEdit:1221615] Shamovsky, V, 2011-02-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF6 binding to IRAK2 stimulates its oligomerizartion upon TLR7 or TLR21 stimulation
output	[Complex:994001] oligo TRAF6 : p-IRAK2 [endosome membrane] [Gallus gallus]
precedingEvent	[Reaction:532630] p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 [Gallus gallus] [Reaction:532632] TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 [Gallus gallus]
releaseDate	2011-03-15
reviewed	[InstanceEdit:1112618] D'Eustachio, P, 2010-12-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1225058] R-GGA-573297.2
summation	[Summation:571290] There is little experimental data about mammalian IRAK2 medi...
(hasEvent)	[Pathway:573298] NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation [Gallus gallus]
(precedingEvent)	[BlackBoxEvent:571318] Autoubiquitination of oligoTRAF6 bound to p-IRAK2 [Gallus gallus]
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No pathways have been reviewed or authored by TRAF6 binding to IRAK2 stimulates its oligomerizartion upon TLR7 or TLR21 stimulation (573297)