Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Activated TRAF6 synthesizes free K63 linked pUb chains

Class:Id	BlackBoxEvent:573294
_displayName	Activated TRAF6 synthesizes free K63 linked pUb chains
_doRelease	TRUE
_timestamp	2024-07-16 19:49:16
authored	[InstanceEdit:1094913] Shamovsky, V, 2010-11-30
catalystActivity	[CatalystActivity:433984] ubiquitin-ubiquitin ligase activity of oligo pUb-TRAF6 : p-IRAK2 [endosome membrane]
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:573295] Shamovsky, V, 2010-04-09
edited	[InstanceEdit:1221606] Shamovsky, V, 2011-02-24
goBiologicalProcess	[GO_BiologicalProcess:436928] free ubiquitin chain polymerization
inferredFrom	[Polymerisation:450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation [Homo sapiens]
input	[DefinedSet:434147] Ubiquitin [cytosol] [Gallus gallus] [DefinedSet:434147] Ubiquitin [cytosol] [Gallus gallus] [DefinedSet:434147] Ubiquitin [cytosol] [Gallus gallus]
literatureReference	[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains [LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK
modified	[InstanceEdit:993985] Shamovsky, V, 2010-11-05 [InstanceEdit:1216498] Shamovsky, V, 2011-02-14 [InstanceEdit:1220566] Shamovsky, V, 2011-02-21 [InstanceEdit:1221615] Shamovsky, V, 2011-02-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915824] D'Eustachio, Peter, 2024-07-16
name	Activated TRAF6 synthesizes free K63 linked pUb chains
output	[Polymer:451962] free K63_polyubiquitin chain [cytosol] [Gallus gallus]
precedingEvent	[BlackBoxEvent:571318] Autoubiquitination of oligoTRAF6 bound to p-IRAK2 [Gallus gallus] [Reaction:573297] TRAF6 binding to IRAK2 stimulates its oligomerizartion upon TLR7 or TLR21 stimulation [Gallus gallus]
releaseDate	2011-03-15
requiredInputComponent	[Complex:433960] UBE2N : UBE2V complex [cytosol] [Gallus gallus]
reviewed	[InstanceEdit:1112618] D'Eustachio, P, 2010-12-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1225027] R-GGA-573294.3
summation	[Summation:446233] TRAF6 generates unanchored Lys63-linked polyubiquitin chains...
(hasEvent)	[Pathway:573298] NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation [Gallus gallus]
(precedingEvent)	[Reaction:573296] Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation [Gallus gallus]
[Change default viewing format]

No pathways have been reviewed or authored by Activated TRAF6 synthesizes free K63 linked pUb chains (573294)