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Details on Person UniProt:P51161 FABP6
| Class:Id | ReferenceGeneProduct:57295 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-128 added on Sat February 7 2015;initiator methionine:1 for 57295 removed on Fri Nov 03 2023;initiator methionine: for 57295 added on Fri Nov 03 2023;initiator methionine: for 57295 removed on Fri Aug 15 2025;initiator methionine:1 for 57295 added on Fri Aug 15 2025 |
| _displayName | UniProt:P51161 FABP6 |
| _timestamp | 2025-08-15 21:52:46 |
| chain | initiator methionine:1 chain:2-128 |
| checksum | 173CBC5DBEDADDE1 |
| comment | FUNCTION Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity).FUNCTION Essential for the survival of colon cancer cells to bile acid-induced apoptosis.SUBCELLULAR LOCATION Localized close to nucleus on the apical side of both normal and neoplastic cells.ALTERNATIVE PRODUCTS Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level).INDUCTION Isoform 1 is up-regulated by chenodeoxycholic acid (CDCA) via the FXR transcription pathway. Isoform 2 is up-regulated by NF-kappa-B and in all stages of colorectal adenocarcinoma. Isoform 1 is not up-regulated in all stages of colorectal adenocarcinoma.DOMAIN Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Can bind at least two ligands per molecule, however, the stoichiometry is debated.SIMILARITY Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. |
| description | recommendedName: Gastrotropin shortName: GT alternativeName: Fatty acid-binding protein 6 alternativeName: Ileal lipid-binding protein shortName: ILBP alternativeName: Intestinal 15 kDa protein shortName: I-15P alternativeName: Intestinal bile acid-binding protein shortName: I-BABP |
| geneName | FABP6 ILBP ILLBP |
| identifier | P51161 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative promoter usage Cytoplasm Lipid transport Lipid-binding Membrane Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | FABP6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001762] ENSEMBL:ENSG00000170231 FABP6 [Homo sapiens] |
| secondaryIdentifier | FABP6_HUMAN Q07DR7 Q8TBI3 Q9UGI7 |
| sequenceLength | 128 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8966538] UniProt:P51161-1 FABP6 [Homo sapiens] [ReferenceIsoform:8966539] UniProt:P51161-2 FABP6 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:194158] FABP6 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P51161 FABP6 (57295)
