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Details on Person UniProt:P26951 IL3RA
| Class:Id | ReferenceGeneProduct:57263 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Fri February 6 2015;chain:19-378 added on Fri February 6 2015 |
| _displayName | UniProt:P26951 IL3RA |
| _timestamp | 2025-05-21 21:37:13 |
| chain | signal peptide:1-18 chain:19-378 |
| checksum | 716CE1803F2E5FC0 |
| comment | FUNCTION Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:10527461). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity).SUBUNIT Interacts with IL3 (PubMed:29374162). Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.INTERACTION The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.DOMAIN The box 1 motif is required for JAK interaction and/or activation.PTM Ubiquitinated by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome. Ubiquitinated by RNF128 via 'Lys-27'-linked polyubiquitination, facilitating its degradation through the lysosomal pathway (PubMed:38702781).MISCELLANEOUS The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.SIMILARITY Belongs to the type I cytokine receptor family. Type 5 subfamily. |
| description | recommendedName: Interleukin-3 receptor subunit alpha shortName: IL-3 receptor subunit alpha shortName: IL-3R subunit alpha shortName: IL-3R-alpha shortName: IL-3RA cdAntigenNameCD123/cdAntigenName |
| geneName | IL3RA IL3R |
| identifier | P26951 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein Membrane Proteomics identification Receptor Reference proteome Signal Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | IL3RA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003586] ENSEMBL:ENSG00000185291 IL3RA [Homo sapiens] |
| secondaryIdentifier | IL3RA_HUMAN A8K3F3 B9VI81 Q5HYQ7 Q5HYQ8 Q9UEH7 |
| sequenceLength | 378 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8976054] UniProt:P26951-1 IL3RA [Homo sapiens] [ReferenceIsoform:8976055] UniProt:P26951-2 IL3RA [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:450037] IL3RA [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:879938] IL3RA [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P26951 IL3RA (57263)
