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Details on Person UniProt:P14784 IL2RB
| Class:Id | ReferenceGeneProduct:57256 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Sat February 7 2015;chain:27-551 added on Sat February 7 2015 |
| _displayName | UniProt:P14784 IL2RB |
| _timestamp | 2024-11-03 19:51:42 |
| chain | signal peptide:1-26 chain:27-551 |
| checksum | 1A76FA1936BB7EE6 |
| comment | FUNCTION Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770, PubMed:31040185).SUBUNIT Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.SUBUNIT (Microbial infection) Interacts with HTLV-1 accessory protein p12I.INTERACTION The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.DOMAIN The box 1 motif is required for JAK interaction and/or activation.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the type I cytokine receptor family. Type 4 subfamily. |
| description | recommendedName: Interleukin-2 receptor subunit beta shortName: IL-2 receptor subunit beta shortName: IL-2R subunit beta shortName: IL-2RB alternativeName: High affinity IL-2 receptor subunit beta alternativeName: fullName evidence="13"Interleukin-15 receptor subunit beta alternativeName: p70-75 shortName: p75 cdAntigenNameCD122/cdAntigenName |
| geneName | IL2RB IL15RB |
| identifier | P14784 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disease variant Disulfide bond Glycoprotein Host-virus interaction Membrane Proteomics identification Receptor Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | IL2RB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987886] ENSEMBL:ENSG00000100385 IL2RB [Homo sapiens] |
| secondaryIdentifier | IL2RB_HUMAN B2R765 |
| sequenceLength | 551 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:197876] IL2RB [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:452093] p-Y364,Y418,Y536-IL2RB [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:507932] p-5Y-IL2RB [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8983172] IL2RB [endosome] [Homo sapiens] [EntityWithAccessionedSequence:9009733] p-Y-IL2RB [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:452120] O4'-phospho-L-tyrosine at 364 [ModifiedResidue:507916] O4'-phospho-L-tyrosine at 384 [ModifiedResidue:507918] O4'-phospho-L-tyrosine at 387 [ModifiedResidue:507920] O4'-phospho-L-tyrosine at 536 [ModifiedResidue:507931] O4'-phospho-L-tyrosine at 418 [ModifiedResidue:507942] O4'-phospho-L-tyrosine at 381 [ModifiedResidue:9009722] O4'-phospho-L-tyrosine at unknown position |
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No pathways have been reviewed or authored by UniProt:P14784 IL2RB (57256)
