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Details on Person UniProt:P01589 IL2RA
| Class:Id | ReferenceGeneProduct:57254 |
|---|---|
| _chainChangeLog | signal peptide:1-21 added on Fri February 6 2015;chain:22-272 added on Fri February 6 2015 |
| _displayName | UniProt:P01589 IL2RA |
| _timestamp | 2025-08-15 21:53:36 |
| chain | signal peptide:1-21 chain:22-272 |
| checksum | 83D907C8C81D2C0E |
| comment | FUNCTION Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.SUBUNIT Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.INTERACTION Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.ONLINE INFORMATION IL2RA mutation db |
| description | recommendedName: Interleukin-2 receptor subunit alpha shortName: IL-2 receptor subunit alpha shortName: IL-2-RA shortName: IL-2R subunit alpha shortName: IL2-RA alternativeName: TAC antigen alternativeName: p55 cdAntigenNameCD25/cdAntigenName |
| geneName | IL2RA |
| identifier | P01589 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Diabetes mellitus Disease variant Disulfide bond Glycoprotein Immunity Membrane Proteomics identification Receptor Reference proteome Repeat Signal Sushi Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | IL2RA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8877386] ENSEMBL:ENSG00000134460 IL2RA [Homo sapiens] |
| secondaryIdentifier | IL2RA_HUMAN Q5W007 |
| sequenceLength | 272 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:450046] IL2RA [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P01589 IL2RA (57254)
