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Details on Person UniProt:P22301 IL10
| Class:Id | ReferenceGeneProduct:57220 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Fri February 6 2015;chain:19-178 added on Fri February 6 2015 |
| _displayName | UniProt:P22301 IL10 |
| _timestamp | 2026-02-20 22:00:04 |
| chain | signal peptide:1-18 chain:19-178 |
| checksum | 6825E9FA4337CDE4 |
| comment | FUNCTION Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF (PubMed:11564774, PubMed:1940799, PubMed:7512027). Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).SUBUNIT Homodimer (PubMed:11485736, PubMed:15837194). Interacts with IL10RA and IL10RB (PubMed:16982608).INTERACTION Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.POLYMORPHISM A polymorphism in IL10 promoter region is associated with resistance to graft-versus-host disease (GVHDS) [MIM:614395]. GVHDS is a major complication of allogeneic bone marrow transplantation, in which mature donor T-cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe inflammatory disease.SIMILARITY Belongs to the IL-10 family.ONLINE INFORMATION Interleukin-10 entry |
| description | recommendedName: Interleukin-10 shortName: IL-10 alternativeName: Cytokine synthesis inhibitory factor shortName: CSIF |
| geneName | IL10 |
| identifier | P22301 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytokine Direct protein sequencing Disulfide bond Glycoprotein Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | IL10 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6790021] ENSEMBL:ENSG00000136634 IL10 [Homo sapiens] |
| secondaryIdentifier | IL10_HUMAN |
| sequenceLength | 178 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:447125] IL10 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9986324] IL10 [endoplasmic reticulum lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P22301 IL10 (57220)
