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Details on Person UniProt:P01591 JCHAIN
| Class:Id | ReferenceGeneProduct:57190 |
|---|---|
| _chainChangeLog | signal peptide:1-22 added on Fri February 6 2015;chain:23-159 added on Fri February 6 2015 |
| _displayName | UniProt:P01591 JCHAIN |
| _timestamp | 2024-11-03 20:19:30 |
| chain | signal peptide:1-22 chain:23-159 |
| checksum | B7835C02CCC0CB05 |
| comment | FUNCTION Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component.SUBUNIT Part of the secretory IgA (sIgA) complex that consists of two, four or five IgA monomers, and two additional non-Ig polypeptides, namely the JCHAIN and the secretory component (the proteolytic product of PIGR) (PubMed:32029686). Part of the secretory IgM (sIgM) complex that consists of five IgM monomers, and two additional non-Ig polypeptides, namely the JCHAIN and the secretory component (the proteolytic product of PIGR) (PubMed:32029686, PubMed:32029689). JCHAIN-containing IgM interacts (via CH4 domain) with FCRM (via Ig-like domain) (PubMed:37095205). |
| description | recommendedName: Immunoglobulin J chain alternativeName: fullName evidence="14"Joining chain of multimeric IgA and IgM |
| geneName | JCHAIN IGCJ IGJ |
| identifier | P01591 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Disulfide bond Glycoprotein Proteomics identification Pyrrolidone carboxylic acid Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | JCHAIN |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994272] ENSEMBL:ENSG00000132465 JCHAIN [Homo sapiens] |
| secondaryIdentifier | IGJ_HUMAN |
| sequenceLength | 159 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8858030] JCHAIN [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P01591 JCHAIN (57190)
