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Details on Person UniProt:P60843 Eif4a1
| Class:Id | ReferenceGeneProduct:57136 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-406 added on Fri February 6 2015;initiator methionine:1 for 57136 removed on Fri Nov 03 2023;initiator methionine: for 57136 added on Fri Nov 03 2023;initiator methionine: for 57136 removed on Fri Aug 15 2025;initiator methionine:1 for 57136 added on Fri Aug 15 2025 |
| _displayName | UniProt:P60843 Eif4a1 |
| _timestamp | 2026-02-20 21:49:57 |
| chain | initiator methionine:1 chain:2-406 |
| checksum | 6EF89939F3045420 |
| comment | FUNCTION ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (By similarity).CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and UPF2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1. Interacts with PDCD4; this interferes with the interaction between EIF4A and EIF4G. Interacts with RBM4 (By similarity). Interacts with DDX3X in an RNA-independent manner (By similarity). Interacts with PKP1 (via N-terminus); the interaction promotes EIF4A1 recruitment to the cap-dependent translation complex and EIF4A1 ATPase activity (By similarity). Interacts with CEP112 (PubMed:39349455).INTERACTION Colocalizes with PKP1 in stress granules following arsenate or hydrogen peroxide treatment.SIMILARITY Belongs to the DEAD box helicase family. eIF4A subfamily. |
| description | recommendedName: Eukaryotic initiation factor 4A-I shortName: eIF-4A-I shortName: eIF4A-I ecNumber: 3.6.4.13 alternativeName: ATP-dependent RNA helicase eIF4A-1 |
| geneName | Eif4a1 Ddx2a Eif4a |
| identifier | P60843 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ATP-binding Cell membrane Cytoplasm Helicase Hydrolase Initiation factor Isopeptide bond Membrane Nucleotide-binding Phosphoprotein Protein biosynthesis Reference proteome RNA-binding Ubl conjugation |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Eif4a1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | IF4A1_MOUSE P04765 Q61516 |
| sequenceLength | 406 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9817636] Eif4a1 [cytosol] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P60843 Eif4a1 (57136)
