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Details on Person In mammals activated IRAK4 phosphorylates both IRAK1 and IRA...

Class:Id	Summation:570878
_displayName	In mammals activated IRAK4 phosphorylates both IRAK1 and IRA...
_timestamp	2011-02-21 19:26:45
created	[InstanceEdit:570884] Shamovsky, V, 2010-04-09
literatureReference	[LiteratureReference:434579] The avian Toll-Like receptor pathway--subtle differences amidst general conformity [LiteratureReference:446698] Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 [LiteratureReference:570877] Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control
modified	[InstanceEdit:975750] Shamovsky, V, 2010-10-04 [InstanceEdit:977266] D'Eustachio, P, 2010-10-15 [InstanceEdit:1220566] Shamovsky, V, 2011-02-21
text	In mammals activated IRAK4 phosphorylates both IRAK1 and IRAK2. Activated IRAK1 and IRAK2 in turn induce NFkB and AP-1 intracellular signaling cascades mediated by TRAF6. Bioinformatic analysis reveals no evidence of IRAK1 in the chicken genome. It is possible that the chicken TLR pathway utilizes only IRAK-2, which shares 47% amino acid sequence identity with human IRAK2.
(summation)	[Reaction:433864] IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88 [Gallus gallus] [Reaction:434047] phosphorylation of IRAK2 by activated IRAK4 [Gallus gallus] [Reaction:571324] IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex [Gallus gallus] [Reaction:571327] IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex [Gallus gallus] [Reaction:977237] IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex [Gallus gallus] [Reaction:977239] Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2 [Gallus gallus]
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