Query author contributions in Reactome
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Details on Person UniProt:P41134 ID1
| Class:Id | ReferenceGeneProduct:57050 |
|---|---|
| _chainChangeLog | chain:1-155 added on Fri February 6 2015 |
| _displayName | UniProt:P41134 ID1 |
| _timestamp | 2024-11-03 20:05:43 |
| chain | chain:1-155 |
| checksum | 480287384B667161 |
| comment | FUNCTION Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity).SUBUNIT Heterodimer with other HLH proteins. Interacts with COPS5, IFI204, GATA4 and NKX2-5 (By similarity). Interacts with CLOCK and BMAL1.INTERACTION Additional isoforms seem to exist.DEVELOPMENTAL STAGE Expression correlates with proliferation in some types of cells. |
| description | recommendedName: DNA-binding protein inhibitor ID-1 alternativeName: Class B basic helix-loop-helix protein 24 shortName: bHLHb24 alternativeName: Inhibitor of DNA binding 1 alternativeName: Inhibitor of differentiation 1 |
| geneName | ID1 BHLHB24 ID |
| identifier | P41134 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Biological rhythms Cytoplasm Developmental protein Nucleus Proteomics identification Reference proteome Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ID1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993083] ENSEMBL:ENSG00000125968 ID1 [Homo sapiens] |
| secondaryIdentifier | ID1_HUMAN A8K537 E1P5L4 O00651 O00652 Q16371 Q16377 Q5TE66 Q5TE67 Q969Z7 Q9H0Z5 Q9H109 |
| sequenceLength | 155 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:148695] UniProt:P41134-2 ID1 [Homo sapiens] [ReferenceIsoform:403964] UniProt:P41134-1 ID1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:2534101] ID1 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P41134 ID1 (57050)
