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Details on Person UniProt:Q14197 MRPL58
| Class:Id | ReferenceGeneProduct:57048 |
|---|---|
| _chainChangeLog | transit peptide:1-29 added on Fri February 6 2015;chain:30-206 added on Fri February 6 2015 |
| _displayName | UniProt:Q14197 MRPL58 |
| _timestamp | 2025-02-21 19:28:43 |
| chain | transit peptide:1-29 chain:30-206 |
| checksum | 663BF52443D41540 |
| comment | FUNCTION Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit (PubMed:20186120, PubMed:33878294). Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation (PubMed:33878294). Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (PubMed:20186120, PubMed:33878294).CATALYTIC ACTIVITY an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)SUBUNIT Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:20186120, PubMed:25278503, PubMed:25838379, PubMed:28892042, PubMed:35177605). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.SUBCELLULAR LOCATION Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.PTM Methylation of glutamine in the GGQ triplet by HEMK1.SIMILARITY Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily.CAUTION Was initially thought to promote the termination of non-canonical termination stop codons AGG and AGA (PubMed:24352605). However, it was later shown that termination of non-canonical termination stop codons is mediated by MTRF1 (PubMed:37141370).CAUTION In contrast to other members of the family, lacks the regions that come into close contact with the mRNA in the ribosomal A-site and determine the STOP codon specificity, explaining the loss of codon specificity for translation release factor activity. |
| description | recommendedName: fullName evidence="12"Large ribosomal subunit protein mL62 alternativeName: fullName evidence="16"39S ribosomal protein L58, mitochondrial shortName: MRP-L58 alternativeName: Digestion substraction 1 shortName: DS-1 alternativeName: Immature colon carcinoma transcript 1 protein alternativeName: fullName evidence="13"Peptidyl-tRNA hydrolase ICT1, mitochondrial ecNumber evidence="2"3.1.1.29 |
| geneName | MRPL58 DS1 ICT1 |
| identifier | Q14197 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Hydrolase Methylation Mitochondrion Protein biosynthesis Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MRPL58 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001199] ENSEMBL:ENSG00000167862 MRPL58 [Homo sapiens] |
| secondaryIdentifier | ICT1_HUMAN B2RAD1 Q53HM7 Q53Y11 |
| sequenceLength | 206 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5368175] ICT1 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:5624366] ICT1 [mitochondrial inner membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q14197 MRPL58 (57048)
