Query author contributions in Reactome
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Details on Person UniProt:O60725 ICMT
| Class:Id | ReferenceGeneProduct:57042 |
|---|---|
| _chainChangeLog | chain:1-284 added on Sat February 7 2015 |
| _displayName | UniProt:O60725 ICMT |
| _timestamp | 2024-11-03 19:56:42 |
| chain | chain:1-284 |
| checksum | C86741B13ACA611C |
| comment | FUNCTION Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.CATALYTIC ACTIVITY [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteineACTIVITY REGULATION Competitively inhibited by N-acetyl-S-trans,trans-farnesyl-l-cysteine (AFC).INTERACTION Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.SIMILARITY Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. |
| description | recommendedName: Protein-S-isoprenylcysteine O-methyltransferase ecNumber evidence="6"2.1.1.100 alternativeName: Isoprenylcysteine carboxylmethyltransferase alternativeName: Prenylated protein carboxyl methyltransferase shortName: PPMT alternativeName: Prenylcysteine carboxyl methyltransferase shortName: pcCMT |
| geneName | ICMT PCCMT |
| identifier | O60725 |
| isSequenceChanged | FALSE |
| keyword | Endoplasmic reticulum Membrane Methyltransferase Proteomics identification Reference proteome S-adenosyl-L-methionine Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ICMT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004159] ENSEMBL:ENSG00000116237 ICMT [Homo sapiens] |
| secondaryIdentifier | ICMT_HUMAN Q6FHT0 |
| sequenceLength | 284 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6788651] ICMT [endoplasmic reticulum membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O60725 ICMT (57042)
