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Details on Person CASP8(1-479) [cytosol]

Class:IdEntityWithAccessionedSequence:57031
_displayNameCASP8(1-479) [cytosol]
_timestamp2013-05-03 18:44:28
compartment[Compartment:70101] cytosol
endCoordinate479
modified[InstanceEdit:109917] Joshi-Tope, G, 2004-01-22 15:11:19
[InstanceEdit:110070] Joshi-Tope, G, 2004-01-28 14:40:07
[InstanceEdit:113466] Schmidt, EE, 2004-05-17 04:24:53
[InstanceEdit:113604] Schmidt, EE, 2004-06-09 05:34:08
[InstanceEdit:3132750] Wu, G, 2013-02-13
[InstanceEdit:3211600] Jupe, S, 2013-03-07
[InstanceEdit:3322333] Wu, G, 2013-05-03
[InstanceEdit:3322334] Wu, G, 2013-05-03
nameCASP8(1-479)
Caspase-8 precursor
ICE-like apoptotic protease 5
MORT1-associated CED-3 homolog
MACH
FADD-homologous ICE/CED-3- like protease
FADD-like ICE
FLICE
Apoptotic cysteine protease
Apoptotic protease Mch-5
CAP4
referenceEntity[ReferenceGeneProduct:57032] UniProt:Q14790 CASP8 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:362980] R-HSA-57031.1
startCoordinate1
(activeUnit)[CatalystActivity:2562582] cysteine-type endopeptidase activity of activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
[CatalystActivity:9013890] cysteine-type endopeptidase activity of activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
(hasComponent)[Complex:75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] [Homo sapiens]
[Complex:140976] TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] [Homo sapiens]
[Complex:141133] TNFSF10:TNFRSF10B:FADD:CASP8(1-479) [plasma membrane] [Homo sapiens]
[Complex:2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] [Homo sapiens]
[Complex:2671817] procaspase-8 dimer [cytosol] [Homo sapiens]
[Complex:3371390] TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] [Homo sapiens]
[Complex:3465443] DISC:procaspase-8 [plasma membrane] [Homo sapiens]
[Complex:3465499] FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] [Homo sapiens]
[Complex:3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] [Homo sapiens]
[Complex:5637468] TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] [Homo sapiens]
List all 14 refering instances
(hasMember)[CandidateSet:622416] Long prodomain caspases [cytosol] [Homo sapiens]
[DefinedSet:933463] CASP8(1-479), CASP10(1-521) [cytosol] [Homo sapiens]
(input)[Reaction:73945] FAS-mediated dimerization of procaspase-8 [Homo sapiens]
[Reaction:75146] TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 [Homo sapiens]
[Reaction:75240] TRADD:TRAF2:RIP1:FADD binds pro-caspase 8 [Homo sapiens]
[Reaction:83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 [Homo sapiens]
[Reaction:141156] TRAIL-mediated dimerization of procaspase-8 [Homo sapiens]
[Reaction:141159] TNF-mediated dimerization of procaspase-8 [Homo sapiens]
[Reaction:2562541] TLR4-induced ripoptosome assembly [Homo sapiens]
[Reaction:3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling [Homo sapiens]
[Reaction:5334738] HPV Suppressed TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-8 [Homo sapiens]
[Reaction:5334739] HPV Suppressed FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 [Homo sapiens]
List all 14 refering instances
(updatedInstance)[_UpdateTracker:9880260] Update Tracker - [EntityWithAccessionedSequence:57031] CASP8(1-479) [cytosol] - v44:[modifyEndCoordinate, modifyStartCoordinate]
[_UpdateTracker:9883423] Update Tracker - [EntityWithAccessionedSequence:57031] CASP8(1-479) [cytosol] - v45:[addName, modifyEndCoordinate, modifyStartCoordinate]
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No pathways have been reviewed or authored by CASP8(1-479) [cytosol] (57031)
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