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Details on Person UniProt:Q9UMF0 ICAM5
| Class:Id | ReferenceGeneProduct:57012 |
|---|---|
| _chainChangeLog | signal peptide:1-31 added on Sat February 7 2015;chain:32-924 added on Sat February 7 2015 |
| _displayName | UniProt:Q9UMF0 ICAM5 |
| _timestamp | 2026-02-20 22:44:24 |
| chain | signal peptide:1-31 chain:32-924 |
| checksum | 97D0A9467BD16D30 |
| comment | FUNCTION Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring neuron cell-leukocyte adhesion (PubMed:8995416). Creates homophilic cell adhesion promoting dendritogenesis and arborization of hippocampal neurons (PubMed:10893271).SUBUNIT Homotetramer.INTERACTION At uropodium and cell-cell contact sites creates homophilic adhesion.TISSUE SPECIFICITY Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon. Brain specific expression (PubMed:9828136). Within the brain, only expressed in regions derived from the telencephalon (PubMed:9828136). Highly expressed in the hippocampus and cerebral cortex, followed by the amygdala, caudate nucleus, occipital pole, frontal lobe, temporal lobe, and putamen (PubMed:9828136). Lower expressed in the corpus callosum, subthalamic nucleus, and thalamus (PubMed:9828136).DOMAIN Ig-like C2-type 1 domain mediates neuronal homophilic adhesion with Ig-like C2-type 4-5 domains.SIMILARITY Belongs to the immunoglobulin superfamily. ICAM family. |
| description | recommendedName: fullName evidence="12"Intercellular adhesion molecule 5 shortName evidence="12"ICAM-5 alternativeName: fullName evidence="11 12"Telencephalin |
| geneName | ICAM5 TLCN TLN |
| identifier | Q9UMF0 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell adhesion Cell membrane Cell projection Disulfide bond Glycoprotein Immunoglobulin domain Membrane Phosphoprotein Postsynaptic cell membrane Proteomics identification Reference proteome Repeat Signal Synapse Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ICAM5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002997] ENSEMBL:ENSG00000105376 ICAM5 [Homo sapiens] |
| secondaryIdentifier | ICAM5_HUMAN Q9Y6F3 |
| sequenceLength | 924 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:197684] ICAM5 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9UMF0 ICAM5 (57012)
