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Details on Person UniProt:P05362 ICAM1
| Class:Id | ReferenceGeneProduct:57004 |
|---|---|
| _chainChangeLog | signal peptide:1-27 added on Sat February 7 2015;chain:28-532 added on Sat February 7 2015 |
| _displayName | UniProt:P05362 ICAM1 |
| _timestamp | 2026-02-20 22:11:01 |
| chain | signal peptide:1-27 chain:28-532 |
| checksum | 550089365A733AFB |
| comment | FUNCTION Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength (PubMed:3086451, PubMed:3340213, PubMed:38195629). Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (PubMed:17875742). Promotes cell aggregation in epithelial cells through interaction with MUC1 (PubMed:11173916).FUNCTION (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.FUNCTION (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.FUNCTION (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.SUBUNIT Homodimer (PubMed:12526797, PubMed:15099525). Interacts with MUC1 and promotes cell aggregation in epithelial cells (PubMed:11173916). Interacts with ARHGEF26/SGEF (PubMed:17875742). Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells (PubMed:23858057).SUBUNIT (Microbial infection) Interacts with major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243).SUBUNIT (Microbial infection) Interacts with Coxsackievirus A21 capsid proteins (PubMed:11160747, PubMed:16004874, PubMed:9539703).INTERACTION Expressed on non-hematopoietic cells such as vascular endothelial cells, thymic epithelial cells, certain other epithelial cells, and fibroblasts, and on hematopoietic cells such as tissue macrophages, mitogen-stimulated T lymphocyte blasts, and germinal center dendritic cells in tonsils, lymph nodes, and Peyer's patches (PubMed:3086451). Expressed in low amounts on peripheral blood leukocytes (PubMed:3086451).INDUCTION Up-regulated by coagulation factor Xa (F10) in atrial tissues (PubMed:24041930). Up-regulated in atrial tissues by rapid pacing resembling atrial fibrillation (PubMed:24041930). Induced by either inflammatory cytokines (PubMed:3086451, PubMed:3340213).PTM Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.POLYMORPHISM Variant p.Lys56Met, known as ICAM1-Kilifi, may influence susceptibility to cerebral malaria [MIM:611162].SIMILARITY Belongs to the immunoglobulin superfamily. ICAM family.ONLINE INFORMATION Intercellular adhesion molecule entryONLINE INFORMATION Icosahedral capsid structureONLINE INFORMATION ICAM-1 |
| description | recommendedName: fullName evidence="32"Intercellular adhesion molecule 1 shortName evidence="33"ICAM-1 alternativeName: fullName evidence="32"Major group rhinovirus receptor cdAntigenNameCD54/cdAntigenName |
| geneName | ICAM1 |
| identifier | P05362 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell adhesion Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Host cell receptor for virus entry Host-virus interaction Immunoglobulin domain Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ICAM1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6785045] ENSEMBL:ENSG00000090339 ICAM1 [Homo sapiens] |
| secondaryIdentifier | ICAM1_HUMAN B2R6M3 Q5NKV7 Q96B50 |
| sequenceLength | 532 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:197683] ICAM1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9940515] ICAM1 (follicular dendritic cell) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9946339] ICAM1 (GC B cell) [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P05362 ICAM1 (57004)
