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Details on Person UniProt:P05155 SERPING1
| Class:Id | ReferenceGeneProduct:57002 |
|---|---|
| _chainChangeLog | signal peptide:1-22 added on Sat February 7 2015;chain:23-500 added on Sat February 7 2015 |
| _displayName | UniProt:P05155 SERPING1 |
| _timestamp | 2025-08-15 21:23:22 |
| chain | signal peptide:1-22 chain:23-500 |
| checksum | 8B5E874833EA6C05 |
| comment | FUNCTION Serine protease inhibitor, which acrs as a regulator of the classical complement pathway (PubMed:10946292, PubMed:11527969, PubMed:3458172, PubMed:6416294). Forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases (PubMed:10946292, PubMed:3458172, PubMed:6416294). May also regulate blood coagulation, fibrinolysis and the generation of kinins (PubMed:8495195). Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein (PubMed:8495195).SUBUNIT Interacts with MASP1.SUBUNIT (Microbial infection) Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis.INTERACTION Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).PTM Cleaved by C1S in vitro.PTM (Microbial infection) Can be proteolytically cleaved by E.coli stcE.POLYMORPHISM Chymotrypsin uses Ala-465 as its reactive site in normal plasma protease C1 inhibitor, and His-466 as its reactive site in the variant His-466.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the serpin family.SEQUENCE CAUTION C1-inhibitor entryONLINE INFORMATION SERPING1 mutation db |
| description | recommendedName: fullName evidence="43"Plasma protease C1 inhibitor shortName: C1 Inh shortName: C1Inh alternativeName: C1 esterase inhibitor alternativeName: fullName evidence="43"C1-inhibiting factor alternativeName: Serpin G1 |
| geneName | SERPING1 C1IN C1NH |
| identifier | P05155 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Blood coagulation Direct protein sequencing Disease variant Disulfide bond Fibrinolysis Glycoprotein Hemostasis Protease inhibitor Proteomics identification Reference proteome Repeat Secreted Serine protease inhibitor Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SERPING1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996639] ENSEMBL:ENSG00000149131 SERPING1 [Homo sapiens] |
| secondaryIdentifier | IC1_HUMAN A6NMU0 A8KAI9 B2R6L5 B4E1F0 B4E1H2 Q16304 Q547W3 Q59EI5 Q7Z455 Q96FE0 Q9UC49 Q9UCF9 |
| sequenceLength | 500 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8970550] UniProt:P05155-1 SERPING1 [Homo sapiens] [ReferenceIsoform:8970551] UniProt:P05155-2 SERPING1 [Homo sapiens] [ReferenceIsoform:8970552] UniProt:P05155-3 SERPING1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:139868] SERPING1 [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:158296] SERPING1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9650330] SERPING1 P489R [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:9650331] SERPING1 V473M [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:9650346] SERPING1 T189N [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:9650355] SERPING1 Y496* [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:9650362] SERPING1 S170P [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:9650402] SERPING1 A458V [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9650410] SERPING1 Q484* [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:9650415] SERPING1 V288E [endoplasmic reticulum lumen] [Homo sapiens] |
| (referenceSequence) | [NonsenseMutation:9650325] Nonsense mutation at L-tyrosine 496 [ReplacedResidue:9650327] L-threonine 467 replaced with L-proline [ReplacedResidue:9650342] L-valine 473 replaced with L-methionine [ReplacedResidue:9650343] L-serine 170 replaced with L-proline [ReplacedResidue:9650350] L-arginine 466 replaced with L-leucine [ReplacedResidue:9650353] L-leucine 177 replaced with L-proline [FragmentDeletionModification:9650357] Deletion of residues 184 to 228 [NonsenseMutation:9650361] Nonsense mutation at L-glutamine 474 [ReplacedResidue:9650364] L-isoleucine 462 replaced with L-serine [ReplacedResidue:9650374] L-proline 476 replaced with L-leucine |
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No pathways have been reviewed or authored by UniProt:P05155 SERPING1 (57002)
