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Details on Person USP37 deubiquitinates Lys-11-linked polyubiquitin chains fro...
| Class:Id | Summation:5696995 |
|---|---|
| _displayName | USP37 deubiquitinates Lys-11-linked polyubiquitin chains fro... |
| _timestamp | 2016-05-05 15:44:02 |
| created | [InstanceEdit:5696996] Jupe, Steve, 2015-06-01 |
| literatureReference | [LiteratureReference:5696992] Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry |
| modified | [InstanceEdit:8869517] Jupe, Steve, 2016-05-05 |
| text | USP37 deubiquitinates Lys-11-linked polyubiquitin chains from cyclin-A (CCNA1 and CCNA2), which opposes the Lys-11-linked polyubiquitination mediated by the anaphase-promoting complex (APC/C) during G1/S transition, thereby promoting S phase entry. Phosphorylation by CDK2 at Ser-628 during G1/S phase maximizes USP37 deubiquitinase activity (Huang et al. 2011). |
| (summation) | [Reaction:5697009] USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 [Homo sapiens] |
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No pathways have been reviewed or authored by USP37 deubiquitinates Lys-11-linked polyubiquitin chains fro... (5696995)
