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Details on Person tRNA ligase complex ligates tRNA exons

Class:Id	Reaction:5696816
_displayName	tRNA ligase complex ligates tRNA exons
_doRelease	TRUE
_timestamp	2015-10-24 03:48:12
authored	[InstanceEdit:5696808] May, Bruce, 2015-05-29
catalystActivity	[CatalystActivity:5696812] RNA ligase (ATP) activity of tRNA ligase complex [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5696805] May, Bruce, 2015-05-30
edited	[InstanceEdit:5696808] May, Bruce, 2015-05-29
goBiologicalProcess	[GO_BiologicalProcess:17894] tRNA splicing, via endonucleolytic cleavage and ligation
input	[GenomeEncodedEntity:5696797] 3' tRNA exon with 5' hydroxyl [nucleoplasm] [Homo sapiens] [GenomeEncodedEntity:5696785] 5' tRNA exon with 2',3' cyclic phosphate [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5696685] HSPC117 is the essential subunit of a human tRNA splicing ligase complex [LiteratureReference:5696687] Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors
modified	[InstanceEdit:6784528] May, Bruce, 2015-06-20 [InstanceEdit:6784590] May, Bruce, 2015-06-21 [InstanceEdit:6790493] May, Bruce, 2015-08-10 [InstanceEdit:6792692] May, Bruce, 2015-08-25 [InstanceEdit:6806694] May, Bruce, 2015-10-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	tRNA ligase complex ligates tRNA exons
output	[GenomeEncodedEntity:5696762] Spliced tRNA with 3' CCA [nucleoplasm] [Homo sapiens] [SimpleEntity:164121] AMP [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm]
precedingEvent	[Reaction:5696813] TSEN complex cleaves the intron from pre-tRNA [Homo sapiens] [Reaction:5696807] TRNT1 polymerizes CCA at the 3' end of pre-tRNA [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796914] R-HSA-5696816.3
summation	[Summation:6784538] The RNA ligase complex ligates tRNA exons yielding intact, s...
(hasEvent)	[Pathway:6784531] tRNA processing in the nucleus [Homo sapiens]
(precedingEvent)	[Reaction:6785478] Processed tRNA binds XPOT and RAN:GTP [Homo sapiens]
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No pathways have been reviewed or authored by tRNA ligase complex ligates tRNA exons (5696816)