Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person ELAC2 cleaves the 3' end of pre-tRNA

Class:Id	Reaction:5696815
_displayName	ELAC2 cleaves the 3' end of pre-tRNA
_doRelease	TRUE
_timestamp	2015-10-24 03:30:53
authored	[InstanceEdit:5696808] May, Bruce, 2015-05-29
catalystActivity	[CatalystActivity:5696814] tRNA-specific ribonuclease activity of ELAC2 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643788] tRNA-specific ribonuclease activity of ELAC2 [nucleoplasm] Naturally occurring mutations in human mitochondrial pre-tRNASer(UCN) can affect the transfer ribonuclease Z cleavage site, processing kinetics, and substrate secondary structure
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5696805] May, Bruce, 2015-05-30
edited	[InstanceEdit:5696808] May, Bruce, 2015-05-29
goBiologicalProcess	[GO_BiologicalProcess:77784] tRNA 3'-end processing
input	[DefinedSet:6784537] 5' cleaved pre-tRNA [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5696689] Naturally occurring mutations in human mitochondrial pre-tRNASer(UCN) can affect the transfer ribonuclease Z cleavage site, processing kinetics, and substrate secondary structure [LiteratureReference:5696729] Functional analyses for tRNase Z variants: an aspartate and a histidine in the active site are essential for the catalytic activity [LiteratureReference:5696714] The N-terminal half-domain of the long form of tRNase Z is required for the RNase 65 activity [LiteratureReference:6784555] Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs [LiteratureReference:6785454] A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease [LiteratureReference:5696733] Localization of human RNase Z isoforms: dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation
modified	[InstanceEdit:6784528] May, Bruce, 2015-06-20 [InstanceEdit:6784590] May, Bruce, 2015-06-21 [InstanceEdit:6785467] May, Bruce, 2015-06-28 [InstanceEdit:6787743] May, Bruce, 2015-07-16 [InstanceEdit:6790486] May, Bruce, 2015-08-10 [InstanceEdit:6790493] May, Bruce, 2015-08-10 [InstanceEdit:6792692] May, Bruce, 2015-08-25 [InstanceEdit:6806694] May, Bruce, 2015-10-24 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ELAC2 cleaves the 3' end of pre-tRNA
output	[DefinedSet:6784544] 5',3' cleaved pre-tRNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5696810] RNase P cleaves the 5' end of pre-tRNA [Homo sapiens] [Reaction:113454] RNA Polymerase III Termination and release of transcribed RNA [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796913] R-HSA-5696815.4
summation	[Summation:6784575] ELAC2, a RNaseZ activity in humans, endonucleolytically clea...
(hasEvent)	[Pathway:6784531] tRNA processing in the nucleus [Homo sapiens]
(precedingEvent)	[Reaction:5696807] TRNT1 polymerizes CCA at the 3' end of pre-tRNA [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by ELAC2 cleaves the 3' end of pre-tRNA (5696815)