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Details on Person ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH

Class:IdReaction:5696365
_displayNameASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH
_doReleaseTRUE
_timestamp2025-02-22 21:58:43
authored[InstanceEdit:5696168] Jassal, Bijay, 2015-05-28
catalystActivity[CatalystActivity:5696364] omega peptidase activity of ASRGL1 heterodimer [cytosol]
catalystActivityReference[CatalystActivityReference:9939271] omega peptidase activity of ASRGL1 heterodimer [cytosol] The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity
compartment[Compartment:70101] cytosol
created[InstanceEdit:5696360] Jassal, Bijay, 2015-05-28
edited[InstanceEdit:5696168] Jassal, Bijay, 2015-05-28
input[SimpleEntity:5696361] aspartame [cytosol]
[SimpleEntity:29356] H2O [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:5696368] The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity
[LiteratureReference:9939272] Metabolism of aspartame by human and pig intestinal microvillar peptidases
[LiteratureReference:5696378] Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation
[LiteratureReference:5696362] Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis
[LiteratureReference:5696367] Elucidation of the specific function of the conserved threonine triad responsible for human L-asparaginase autocleavage and substrate hydrolysis
modified[InstanceEdit:5696382] Jassal, Bijay, 2015-05-28
[InstanceEdit:6783364] Jassal, Bijay, 2015-06-12
[InstanceEdit:6785238] Jassal, Bijay, 2015-06-26
[InstanceEdit:6785240] Jassal, Bijay, 2015-06-26
[InstanceEdit:6792911] Jassal, Bijay, 2015-08-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9939270] D'Eustachio, Peter, 2025-02-22
nameASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH
output[SimpleEntity:29448] L-Asp [cytosol]
[SimpleEntity:29502] L-Phe [cytosol]
[SimpleEntity:5359061] MeOH [cytosol]
releaseDate2015-09-22
releaseStatusNEW
reviewed[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6796900] R-HSA-5696365.3
summation[Summation:5696363] The human isoaspartyl peptidase/L-asparaginase (ASRGL1) is a...
(hasEvent)[Pathway:8964208] Phenylalanine metabolism [Homo sapiens]
(precedingEvent)[Reaction:71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Homo sapiens]
[Reaction:893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Homo sapiens]
(updatedInstance)[_UpdateTracker:9939842] Update Tracker - [Reaction:5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH - v92:[modifyText, removeLiteratureReference]
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