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Details on Person ACSF2 ligates CoA-SH to MCFA

Class:IdReaction:5696004
_displayNameACSF2 ligates CoA-SH to MCFA
_doReleaseTRUE
_timestamp2025-12-29 22:36:44
authored[InstanceEdit:5695977] Jassal, Bijay, 2015-05-26
catalystActivity[CatalystActivity:5696013] long-chain fatty acid-CoA ligase activity of ACSF2 [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:5696012] Jassal, Bijay, 2015-05-26
crossReference[DatabaseIdentifier:9978274] RHEA:48341
edited[InstanceEdit:5695977] Jassal, Bijay, 2015-05-26
goBiologicalProcess[GO_BiologicalProcess:8047] acyl-CoA metabolic process
input[SimpleEntity:5690531] MCFA [mitochondrial matrix]
[SimpleEntity:113593] ATP [mitochondrial matrix]
[SimpleEntity:29374] CoA-SH [mitochondrial matrix]
isChimericFALSE
literatureReference[LiteratureReference:5696002] Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome
modified[InstanceEdit:6782147] Jassal, Bijay, 2015-06-05
[InstanceEdit:6785240] Jassal, Bijay, 2015-06-26
[InstanceEdit:6792911] Jassal, Bijay, 2015-08-28
[InstanceEdit:8979079] D'Eustachio, Peter, 2017-02-21
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9978272] D'Eustachio, Peter, 2025-12-29
nameACSF2 ligates CoA-SH to MCFA
a medium-chain fatty acid + ATP + CoA => a medium-chain fatty acyl-CoA + AMP + diphosphate
output[SimpleEntity:5690542] MCFA-CoA [mitochondrial matrix]
[SimpleEntity:159448] AMP [mitochondrial matrix]
[SimpleEntity:159450] PPi [mitochondrial matrix]
releaseDate2015-09-22
releaseStatusNEW
reviewed[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6796881] R-HSA-5696004.4
summation[Summation:5696014] Acyl-coenzyme A synthetases (ACSs) catalyse the activation o...
(hasEvent)[Pathway:77289] Mitochondrial Fatty Acid Beta-Oxidation [Homo sapiens]
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No pathways have been reviewed or authored by ACSF2 ligates CoA-SH to MCFA (5696004)