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Details on Person ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA

Class:Id	Reaction:5695957
_displayName	ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA
_doRelease	TRUE
_timestamp	2024-03-20 19:02:48
authored	[InstanceEdit:5695977] Jassal, Bijay, 2015-05-26
catalystActivity	[CatalystActivity:5695982] very long-chain fatty acid-CoA ligase activity of ACSBG1,2 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5695977] Jassal, Bijay, 2015-05-26
crossReference	[DatabaseIdentifier:9865934] RHEA:54537
edited	[InstanceEdit:5695977] Jassal, Bijay, 2015-05-26
input	[SimpleEntity:5695985] VLCFA [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:76194] CoA-SH [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5695997] Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids [LiteratureReference:5695951] The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation. [LiteratureReference:5695947] The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase
modified	[InstanceEdit:6782147] Jassal, Bijay, 2015-06-05 [InstanceEdit:6785240] Jassal, Bijay, 2015-06-26 [InstanceEdit:6792911] Jassal, Bijay, 2015-08-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20
name	ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA a very long-chain fatty acid + ATP + CoA => a very long-chain fatty acyl-CoA + AMP + diphosphate
output	[SimpleEntity:5695971] VLCFA-CoA [cytosol] [SimpleEntity:76577] AMP [cytosol] [SimpleEntity:111294] PPi [cytosol]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796877] R-HSA-5695957.3
summation	[Summation:5695962] Long-chain fatty acid-CoA ligases 1 and 2 (ACSBG1 and 2) are...
(hasEvent)	[Pathway:75876] Synthesis of very long-chain fatty acyl-CoAs [Homo sapiens]
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No pathways have been reviewed or authored by ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (5695957)