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Details on Person SEC16 complex binds SAR1B:GTP:SEC23:SEC24

Class:Id	Reaction:5694417
_displayName	SEC16 complex binds SAR1B:GTP:SEC23:SEC24
_doRelease	TRUE
_timestamp	2015-09-04 20:35:11
authored	[InstanceEdit:5683769] Rothfels, Karen, 2015-03-16
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:5694416] Rothfels, Karen, 2015-05-21
edited	[InstanceEdit:5688570] Rothfels, Karen, 2015-04-17
input	[Complex:5694307] SEC16A:SEC16B [cytosol] [Homo sapiens] [Complex:5694310] TFG hexamer [cytosol] [Homo sapiens] [Complex:5694523] COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5685778] Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells [LiteratureReference:5685811] Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization [LiteratureReference:5685765] Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER [LiteratureReference:5685751] Insights into structural and regulatory roles of Sec16 in COPII vesicle formation at ER exit sites [LiteratureReference:5685773] SEC16 in COPII coat dynamics at ER exit sites [LiteratureReference:5688209] Sec16p potentiates the action of COPII proteins to bud transport vesicles [LiteratureReference:5688216] Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat [LiteratureReference:5688173] Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure [LiteratureReference:5688231] TFG-1 function in protein secretion and oncogenesis [LiteratureReference:5688222] TFG clusters COPII-coated transport carriers and promotes early secretory pathway organization
modified	[InstanceEdit:5694540] Rothfels, Karen, 2015-05-21 [InstanceEdit:6791049] Gillespie, Marc E, 2015-08-17 [InstanceEdit:6791097] Rothfels, Karen, 2015-08-19 [InstanceEdit:6792561] Rothfels, Karen, 2015-08-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SEC16 complex binds SAR1B:GTP:SEC23:SEC24
output	[Complex:5694339] COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:5694522] Inner coat assembly and cargo binding [Homo sapiens] [Reaction:203977] SAR1 Activation And Membrane Binding [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6791049] Gillespie, Marc E, 2015-08-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796853] R-HSA-5694417.2
summation	[Summation:5694397] The multimeric SEC16 complex marks sites of ER exit (ERES) a...
(hasEvent)	[Pathway:204005] COPII-mediated vesicle transport [Homo sapiens]
(precedingEvent)	[Reaction:204008] SEC31:SEC13 and v-SNARE recruitment [Homo sapiens]
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No pathways have been reviewed or authored by SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (5694417)