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Details on Person PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser

Class:Id	Reaction:5694137
_displayName	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser
_doRelease	TRUE
_timestamp	2020-12-10 13:56:12
authored	[InstanceEdit:5694479] Jassal, Bijay, 2015-05-21
catalystActivity	[CatalystActivity:5694152] glycine hydroxymethyltransferase activity of PXLP-K280-SHMT2 tetramer [mitochondrial inner membrane]
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:5694122] Jassal, Bijay, 2015-05-21
edited	[InstanceEdit:5694479] Jassal, Bijay, 2015-05-21
input	[SimpleEntity:5693984] 5,10-methylene-THF [mitochondrial matrix] [SimpleEntity:159549] Gly [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:5694111] Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria
modified	[InstanceEdit:6785140] Jassal, Bijay, 2015-06-25 [InstanceEdit:6785240] Jassal, Bijay, 2015-06-26 [InstanceEdit:6792911] Jassal, Bijay, 2015-08-28 [InstanceEdit:6797954] Jassal, Bijay, 2015-09-16 [InstanceEdit:9644816] Jassal, Bijay, 2019-04-24 [InstanceEdit:9709130] Jassal, Bijay, 2020-12-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser
output	[SimpleEntity:200671] THF [mitochondrial matrix] [SimpleEntity:379732] L-Ser [mitochondrial matrix]
precedingEvent	[Reaction:6797913] SARDH:FAD oxidatively demethylates SARC to Gly [Homo sapiens] [Reaction:6797653] DMGDH:FAD oxidatively demethylates DMGLY to SARC [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796848] R-HSA-5694137.5
summation	[Summation:5694125] Mitochondrial serine hydroxymethyltransferase (SHMT2) contri...
(hasEvent)	[Pathway:196757] Metabolism of folate and pterines [Homo sapiens]
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No pathways have been reviewed or authored by PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (5694137)