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Details on Person GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH

Class:Id	Reaction:5694071
_displayName	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH
_doRelease	TRUE
_timestamp	2026-01-08 13:55:25
authored	[InstanceEdit:5694479] Jassal, Bijay, 2015-05-21
catalystActivity	[CatalystActivity:5694145] lactoylglutathione lyase activity of GLO1 dimer:2xZn2+ [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5694122] Jassal, Bijay, 2015-05-21
edited	[InstanceEdit:5694479] Jassal, Bijay, 2015-05-21
goBiologicalProcess	[GO_BiologicalProcess:172230] methylglyoxal catabolic process
input	[SimpleEntity:29450] GSH [cytosol] [SimpleEntity:5694074] MGXL [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5694146] Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I
modified	[InstanceEdit:5696935] Jassal, Bijay, 2015-06-01 [InstanceEdit:6783205] Jassal, Bijay, 2015-06-11 [InstanceEdit:6785140] Jassal, Bijay, 2015-06-25 [InstanceEdit:6785240] Jassal, Bijay, 2015-06-26 [InstanceEdit:6792911] Jassal, Bijay, 2015-08-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9863123] Stephan, Ralf, 2024-02-27 [InstanceEdit:9978814] D'Eustachio, Peter, 2026-01-08
name	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH GLO1 dimer:2xZn2+ trnasforms glutathione and methylglyoxal to lactoylglutathione
output	[SimpleEntity:5694130] (R)-S-LGSH [cytosol]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796843] R-HSA-5694071.4
summation	[Summation:5694139] Lactoylglutathione lyase (GLO1) catalyses the transformation...
(hasEvent)	[Pathway:70268] Pyruvate metabolism [Homo sapiens] [Pathway:9861990] Methylglyoxal degradation [Homo sapiens]
(precedingEvent)	[Reaction:6783221] HAGH hydrolyses (R)-S-LGSH to GSH and LACT [Homo sapiens]
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No pathways have been reviewed or authored by GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (5694071)