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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of mTOR signalling

Class:IdPathwayDiagram:5694003
_displayNameDiagram of mTOR signalling
_timestamp2026-02-19 17:07:14
created[InstanceEdit:5694002] Jupe, Steve, 2015-05-19
height970
modified[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8952705] Jassal, Bijay, 2016-12-16
[InstanceEdit:9638279] May, Bruce, 2019-03-04
[InstanceEdit:9690476] Jassal, Bijay, 2020-06-01
[InstanceEdit:9830303] Matthews, Lisa, 2023-03-04
[InstanceEdit:9830305] D'Eustachio, Peter, 2023-03-04
[InstanceEdit:9975208] Orlic-Milacic, Marija, 2025-11-28
[InstanceEdit:9975254] Orlic-Milacic, Marija, 2025-11-29
[InstanceEdit:9975673] Orlic-Milacic, Marija, 2025-12-01
[InstanceEdit:9975696] Orlic-Milacic, Marija, 2025-12-02
[InstanceEdit:9975701] Orlic-Milacic, Marija, 2025-12-02
[InstanceEdit:9975702] Orlic-Milacic, Marija, 2025-12-02
[InstanceEdit:9975781] Orlic-Milacic, Marija, 2025-12-03
[InstanceEdit:9975797] Orlic-Milacic, Marija, 2025-12-03
[InstanceEdit:9975972] Orlic-Milacic, Marija, 2025-12-04
[InstanceEdit:9982466] Orlic-Milacic, Marija, 2026-02-17
[InstanceEdit:9982467] Orlic-Milacic, Marija, 2026-02-17
[InstanceEdit:9982468] Orlic-Milacic, Marija, 2026-02-17
[InstanceEdit:9982490] Orlic-Milacic, Marija, 2026-02-17
[InstanceEdit:9982602] Orlic-Milacic, Marija, 2026-02-18
[InstanceEdit:9982610] Orlic-Milacic, Marija, 2026-02-18
[InstanceEdit:9982865] Orlic-Milacic, Marija, 2026-02-19
[InstanceEdit:9982866] Orlic-Milacic, Marija, 2026-02-19
[InstanceEdit:9982867] Orlic-Milacic, Marija, 2026-02-19
[InstanceEdit:9982868] Orlic-Milacic, Marija, 2026-02-19
representedPathway[Pathway:165159] MTOR signalling [Homo sapiens]
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textPosition="109 493"> <Properties> <displayName>p-S183,S221,T246-AKT1S1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.0" relativeY="0.47865768401034303" label="P" trackId="0" reactomeId="377446" /> <org.gk.render.RenderableFeature relativeX="0.34705882352941175" relativeY="1.0" label="P" trackId="0" reactomeId="200159" /> <org.gk.render.RenderableFeature relativeX="0.0" relativeY="0.2646578871691533" label="P" trackId="1" reactomeId="200144" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="3026" reactomeId="70484" position="567 567" bounds="533 551 69 33" textPosition="538 548" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PGK1 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="3136" reactomeId="9975697" position="575 152" bounds="533 141 84 22" textPosition="536 141"> <Properties> <displayName>p-T,p-S-AKT</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.ProcessNode id="3138" reactomeId="1257604" position="574 52" bounds="488 25 172 55" textPosition="509 30"> <Properties> <displayName>PIP3 activates AKT signaling</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="3146" reactomeId="380972" position="195 838" bounds="123 796 144 85" textPosition="128 809" /> <org.gk.render.RenderableEntitySet id="3195" reactomeId="9975788" position="617 730" bounds="585 717 65 26" textPosition="587 719"> <Properties> <displayName>RPS6KB1</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="3200" reactomeId="9975784" position="953 745" bounds="880 733 146 24" textPosition="884 734"> <Properties> <displayName>p-T389/412-RPS6KB1</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="3202" reactomeId="113592" position="682 759" bounds="664 748 36 22" textPosition="667 748" /> <org.gk.render.RenderableChemical id="3203" reactomeId="29370" position="844 796" bounds="823 784 42 25" textPosition="828 785" /> <org.gk.render.RenderableRNA id="3430" reactomeId="9982551" position="1268 532" bounds="1237 510 62 45" textPosition="1238 514"> <Properties> <displayName>AKT1S1 mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableComplex id="3431" reactomeId="9982559" position="1262 671" bounds="1195 653 135 36" textPosition="1199 653" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>AKT1S1 mRNA:miR-142-3p-RISC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="3487" reactomeId="9982581" position="1450 696" bounds="1396 685 108 23" textPosition="1396 685"> <Properties> <displayName>miR-142-3p RISC</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableCompartment id="3520" reactomeId="7660" position="1595 829" bounds="1511 781 169 96" textPosition="1521 835" bgColor="250 240 240" lineColor="255 153 102" insets="1516 787 157 85"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="3528" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableGene id="3528" reactomeId="9982607" position="1591 812" bounds="1548 786 87 52" textPosition="1548 813"> <Properties> <displayName>MIR142 gene</displayName> </Properties> </org.gk.render.RenderableGene> </Nodes> <Edges> <org.gk.render.RenderableReaction id="2" reactomeId="165162" points="794 145, 791 184, 792 204" position="791 184" lineWidth="1.0"> <Inputs> <Input id="3" stoichiometry="3" points="872 140" /> <Input id="4" points="795 123" /> </Inputs> <Outputs> <Output id="5" stoichiometry="3" points="868 204" /> <Output id="6" points="792 243" /> </Outputs> <Catalysts> <Catalyst id="3136" points="623 158" /> </Catalysts> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8" reactomeId="165182" points="988 139, 988 176, 988 210" position="988 176" lineWidth="1.0"> <Inputs> <Input id="9" points="991 108" /> <Input id="3" stoichiometry="3" points="916 139" /> </Inputs> <Outputs> <Output id="11" points="990 240" /> <Output id="5" stoichiometry="3" points="913 205" /> </Outputs> <Catalysts> <Catalyst id="3136" points="623 154" /> </Catalysts> <Properties> <displayName>Phosphorylation of complexed TSC2 by PKB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="18" reactomeId="165195" points="1398 510, 1429 511, 1459 511" position="1429 511" lineWidth="1.0"> <Inputs> <Input id="19" points="1383 526" /> <Input id="20" points="1394 473" /> </Inputs> <Outputs> <Output id="21" points="1469 474" /> <Output id="22" points="1481 528" /> </Outputs> <Properties> <displayName>GTP loading by Rheb</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="23" reactomeId="5653957" points="2253 601, 2253 600, 2251 567" position="2253 600" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="24" points="2239 691" /> <Input id="25" points="2177 626" /> </Inputs> <Outputs> <Output id="26" /> </Outputs> <Properties> <displayName>Rag dimer formation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="27" reactomeId="5653936" points="2146 385, 2147 426, 2231 422" position="2147 426" lineWidth="1.0"> <Inputs> <Input id="28" points="2063 324" /> <Input id="29" points="2242 351" /> <Input id="30" points="2127 323" /> <Input id="31" points="2234 376" /> <Input id="32" points="2193 323" /> </Inputs> <Outputs> <Output id="33" /> </Outputs> <Properties> <displayName>Formation of Ragulator complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="38" reactomeId="5653974" points="2256 477, 2255 478, 2213 471" position="2255 478" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="26" points="2252 523" /> <Input id="33" points="2266 435" /> </Inputs> <Outputs> <Output id="39" /> </Outputs> <Properties> <displayName>Ragulator binds Rag dimers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="40" reactomeId="5653968" points="1764 553, 1764 553, 1669 486" position="1764 553" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="41" points="1800 585" /> <Input id="155" points="1833 484" /> </Inputs> <Outputs> <Output id="42" /> </Outputs> <Properties> <displayName>Ragulator:Rag dimers:SLC38A9 bind mTORC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="47" reactomeId="165680" points="1416 374, 1415 375, 1166 444" position="1415 375" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="21" points="1464 446" /> <Input id="42" points="1570 430" /> </Inputs> <Outputs> <Output id="48" /> </Outputs> <Properties> <displayName>Formation of active mTORC1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="49" reactomeId="5672843" points="1096 533, 925 389, 764 458" position="925 389" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="50" points="1110 550" /> <Input id="48" points="1105 480" /> </Inputs> <Outputs> <Output id="51" /> </Outputs> <Properties> <displayName>AKT1S1 (PRAS40) binds mTORC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="52" reactomeId="377186" points="646 432, 570 403, 471 422" position="570 403" lineWidth="1.0"> <Inputs> <Input id="53" points="632 480" /> <Input id="51" points="694 458" /> </Inputs> <Outputs> <Output id="48" points="1082 438, 974 368, 471 368" /> <Output id="2781" points="492 476" /> <Output id="2779" points="411 492" /> </Outputs> <Catalysts> <Catalyst id="3136" points="574 169" /> </Catalysts> <Properties> <displayName>Activated AKT phosphorylates AKT1S1 (PRAS40)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="61" reactomeId="5672824" points="182 566, 202 625, 187 695" position="202 625" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="62" points="155 600" /> <Input id="2914" points="190 524" /> </Inputs> <Outputs> <Output id="63" /> </Outputs> <Properties> <displayName>Phosphorylated AKT1S1 binds YWHAB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="64" reactomeId="5672828" points="377 544, 324 551, 296 543" position="324 551" lineWidth="1.0"> <Inputs> <Input id="2779" points="392 525" /> <Input id="2910" stoichiometry="2" points="366 595" /> </Inputs> <Outputs> <Output id="2913" stoichiometry="2" points="281 587" /> <Output id="2914" points="237 524" /> </Outputs> <Catalysts> <Catalyst id="48" points="1092 438, 999 336, 362 340" /> </Catalysts> <Properties> <displayName>mTORC1 phosphorylates AKT1S1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="68" reactomeId="165718" points="717 722, 755 720, 833 738" position="755 720" lineWidth="1.0"> <Inputs> <Input id="3195" points="656 727" /> <Input id="3202" points="692 745" /> </Inputs> <Outputs> <Output id="3203" points="841 781" /> <Output id="3200" points="874 740" /> </Outputs> <Catalysts> <Catalyst id="48" points="1084 480" /> </Catalysts> <Inhibitors> <Inhibitor id="73" points="870 499, 754 666" /> <Inhibitor id="206" points="621 811, 755 768" /> </Inhibitors> <Properties> <displayName>mTORC1 phosphorylation of RPS6KB1 (S6K)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="78" reactomeId="165726" points="982 663, 1028 663, 1074 663" position="1028 663" lineWidth="1.0"> <Inputs> <Input id="79" stoichiometry="5" points="951 651" /> <Input id="80" points="955 677" /> </Inputs> <Outputs> <Output id="81" points="1092 678" /> <Output id="82" stoichiometry="5" points="1095 647" /> </Outputs> <Catalysts> <Catalyst id="3200" points="963 727" /> </Catalysts> <Properties> <displayName>Phosphorylation of Ribosomal protein S6 by activated S6K1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="83" reactomeId="165758" points="1268 801, 1310 801, 1352 801" position="1310 801" lineWidth="1.0"> <Inputs> <Input id="84" points="1258 792" /> <Input id="85" points="1252 830" /> </Inputs> <Outputs> <Output id="86" points="1373 827" /> <Output id="87" points="1367 785" /> </Outputs> <Catalysts> <Catalyst id="3200" points="1032 741, 1288 730" /> </Catalysts> <Properties> <displayName>Phosphorylation and inactivation of eEF2K by activated S6K1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="88" reactomeId="165766" points="1045 855, 1075 853, 1100 854" position="1075 853" lineWidth="1.0"> <Inputs> <Input id="89" stoichiometry="3" points="1020 839" /> <Input id="90" points="1020 888" /> </Inputs> <Outputs> <Output id="91" points="1141 878" /> <Output id="92" stoichiometry="3" points="1136 832" /> </Outputs> <Catalysts> <Catalyst id="3200" points="966 763" /> </Catalysts> <Properties> <displayName>Phosphorylation and activation of eIF4G by activated S6K1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="97" reactomeId="165777" points="808 874, 842 874, 870 873" position="842 874" lineWidth="1.0"> <Inputs> <Input id="98" points="787 858" /> <Input id="99" points="768 903" /> </Inputs> <Outputs> <Output id="100" points="890 902" /> <Output id="101" points="888 859" /> </Outputs> <Catalysts> <Catalyst id="3200" points="942 763" /> </Catalysts> <Properties> <displayName>Phosphorylation and activation of eIF4B by activated S6K1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="102" reactomeId="165692" points="420 661, 420 696, 420 723" position="420 696" lineWidth="1.0"> <Inputs> <Input id="103" stoichiometry="2" points="451 638" /> <Input id="104" points="426 606" /> </Inputs> <Outputs> <Output id="105" points="423 752" /> <Output id="106" stoichiometry="2" points="376 728" /> </Outputs> <Catalysts> <Catalyst id="48" points="1056 480" /> </Catalysts> <Inhibitors> <Inhibitor id="51" points="711 500, 658 573" /> <Inhibitor id="206" points="575 811" /> </Inhibitors> <Properties> <displayName>Phosphorylation of 4E-BP1 by activated mTORC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="107" reactomeId="165708" points="424 780, 424 808, 424 841" position="424 808" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="105" /> </Inputs> <Outputs> <Output id="108" points="384 861" /> <Output id="109" points="424 902" /> </Outputs> <Properties> <displayName>Dissociation of phosphorylated 4EBP1 from eIF4E</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="154" interactionType="Activate" points="1484 474, 1587 561" position="1535 517" lineWidth="2.0"> <Inputs> <Input id="21" /> </Inputs> <Outputs> <Output id="110" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="158" reactomeId="8952716" points="2036 521, 2036 521, 1922 479" position="2036 521" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="159" points="2013 476" /> <Input id="39" points="2108 484" /> </Inputs> <Outputs> <Output id="155" /> </Outputs> <Properties> <displayName>SLC38A9 binds Ragulator:Rag dimers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="160" reactomeId="8952726" points="1764 416, 1764 461, 1764 493" position="1764 461" lineWidth="1.0"> <Inputs> <Input id="161" /> </Inputs> <Outputs> <Output id="162" /> </Outputs> <Catalysts> <Catalyst id="155" points="1790 459" /> </Catalysts> <Properties> <displayName>SLC38A9 transports L-Arg from lysosomal lumen to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="203" reactomeId="9679044" points="589 869, 589 870, 589 839" position="589 870" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="204" points="562 891" /> <Input id="205" points="618 890" /> </Inputs> <Outputs> <Output id="206" /> </Outputs> <Properties> <displayName>FKBP1A binds sirolimus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3023" reactomeId="9975250" points="607 528, 567 511, 514 531" position="567 511" lineWidth="1.0"> <Inputs> <Input id="50" points="1085 561" /> <Input id="53" points="651 496" /> </Inputs> <Outputs> <Output id="2779" points="460 519" /> <Output id="2781" points="499 498" /> </Outputs> <Catalysts> <Catalyst id="3026" points="567 548" /> </Catalysts> <Properties> <displayName>PGK1 phosphorylates AKT1S1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="3145" interactionType="Activate" points="574 83, 574 135" position="574 109" lineWidth="2.0"> <Inputs> <Input id="3138" /> </Inputs> <Outputs> <Output id="3136" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="3147" interactionType="Activate" points="1560 598, 1052 586, 934 499" position="1052 586" lineWidth="2.0"> <Inputs> <Input id="110" /> </Inputs> <Outputs> <Output id="73" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="3429" reactomeId="9982562" points="1234 547, 1202 566, 1151 564" position="1202 566" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="3430" /> </Inputs> <Outputs> <Output id="50" /> </Outputs> <Inhibitors> <Inhibitor id="3431" points="1251 650" /> </Inhibitors> <Properties> <displayName>AKT1S1 mRNA translation is inhibited by miR-142-3p</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3486" reactomeId="9982545" points="1399 618, 1363 630, 1306 650" position="1363 630" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3430" points="1302 552" /> <Input id="3487" points="1442 679" /> </Inputs> <Outputs> <Output id="3431" /> </Outputs> <Properties> <displayName>miR-142-3p RISC binds AKT1S1 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3527" reactomeId="9982605" points="1644 788, 1559 704, 1510 699" position="1559 704" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="3528" /> </Inputs> <Outputs> <Output id="3487" /> </Outputs> <Inhibitors> <Inhibitor id="48" points="1166 470, 1276 494" /> </Inhibitors> <Properties> <displayName>miR-142-3p expression is inhibited by mTORC1</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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