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Details on Person PXLP-K754-GLDC dimer decarboxylates Gly

Class:Id	Reaction:5693967
_displayName	PXLP-K754-GLDC dimer decarboxylates Gly
_doRelease	TRUE
_timestamp	2025-02-25 22:17:25
authored	[InstanceEdit:5693960] Jassal, Bijay, 2015-05-19
catalystActivity	[CatalystActivity:5693965] glycine dehydrogenase (decarboxylating) activity of PXLP-K754-GLDC dimer [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:5693960] Jassal, Bijay, 2015-05-19
crossReference	[DatabaseIdentifier:9930734] RHEA:24305
edited	[InstanceEdit:5693960] Jassal, Bijay, 2015-05-19
input	[SimpleEntity:159549] Gly [mitochondrial matrix] [EntityWithAccessionedSequence:6793611] Lipo-K107-GCSH [mitochondrial matrix] [Homo sapiens] [SimpleEntity:113529] H+ [mitochondrial matrix]
internalReviewed	[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
isChimeric	FALSE
literatureReference	[LiteratureReference:5693952] The glycine cleavage system. Molecular cloning of the chicken and human glycine decarboxylase cDNAs and some characteristics involved in the deduced protein structures [LiteratureReference:5693959] The primary structure of human H-protein of the glycine cleavage system deduced by cDNA cloning [LiteratureReference:5693976] Lipoylation of H-protein of the glycine cleavage system. The effect of site-directed mutagenesis of amino acid residues around the lipoyllysine residue on the lipoate attachment
modified	[InstanceEdit:5693975] Jassal, Bijay, 2015-05-19 [InstanceEdit:5694021] Jassal, Bijay, 2015-05-20 [InstanceEdit:6783983] Jassal, Bijay, 2015-06-18 [InstanceEdit:6783986] Jassal, Bijay, 2015-06-18 [InstanceEdit:6785229] Jassal, Bijay, 2015-06-25 [InstanceEdit:6785240] Jassal, Bijay, 2015-06-26 [InstanceEdit:6792577] Jassal, Bijay, 2015-08-25 [InstanceEdit:6792911] Jassal, Bijay, 2015-08-28 [InstanceEdit:6793635] Jassal, Bijay, 2015-09-02 [InstanceEdit:8849191] Jassal, Bijay, 2015-12-14 [InstanceEdit:9644711] D'Eustachio, Peter, 2019-04-17 [InstanceEdit:9644735] D'Eustachio, Peter, 2019-04-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9930615] D'Eustachio, Peter, 2024-12-04 [InstanceEdit:9930741] D'Eustachio, Peter, 2024-12-05 [InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06 [InstanceEdit:9939309] D'Eustachio, Peter, 2025-02-24 [InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	PXLP-K754-GLDC dimer decarboxylates Gly glycine + H(+) + N(6)-((R)-lipoyl)-L-lysyl-(glycine-cleavage complex H protein) => CO2 + N(6)-((R)-S(8)-aminomethyldihydrolipoyl)-L-lysyl-(glycine-cleavage complex H protein)
output	[SimpleEntity:29376] CO2 [mitochondrial matrix] [Complex:5693969] AmMeLipoGCSH:SAMDLL [mitochondrial matrix] [Homo sapiens]
precedingEvent	[Reaction:5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Homo sapiens] [Reaction:5693977] AMT transfers NH2CH2 from GCSH:SAMDLL to THF [Homo sapiens] [Reaction:904864] Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate [Homo sapiens] [Reaction:6784423] HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26 [InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796840] R-HSA-5693967.5
structureModified	[InstanceEdit:9930615] D'Eustachio, Peter, 2024-12-04
summation	[Summation:5693953] The simplest amino acid, glycine, is catabolised by several ...
(hasEvent)	[Pathway:6783984] Glycine degradation [Homo sapiens]
(precedingEvent)	[Reaction:5693977] AMT transfers NH2CH2 from GCSH:SAMDLL to THF [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939785] Update Tracker - [Reaction:5693967] PXLP-K754-GLDC dimer decarboxylates Gly - v92:[removeInput]
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