Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Tissue alpha-L-fucosidase (FUCA1) is a lysosomal enzyme that...

Class:IdSummation:5693806
_displayNameTissue alpha-L-fucosidase (FUCA1) is a lysosomal enzyme that...
_timestamp2015-05-21 09:58:53
created[InstanceEdit:5693803] Jassal, Bijay, 2015-05-18
modified[InstanceEdit:5694122] Jassal, Bijay, 2015-05-21
textTissue alpha-L-fucosidase (FUCA1) is a lysosomal enzyme that removes terminal L-fucose residues from the oligosaccharide chains of N-glycoproteins (NGPs). In humans, FUCA1 encodes the tissue enzyme, whilst FUCA2 encodes plasma alpha-L-fucosidase (Intra et al. 2007). Defects in FUCA1 can cause fucosidosis (FUCA1D; MIM:230000), a rare lysosomal storage disorder characterised by progressive psychomotor deterioration, angiokeratoma and growth retardation (Willems et al. 1999).
(summation)[Reaction:5693807] FUCA1 hydrolyses NGP:1,6-GlcNAc [Homo sapiens]
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