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Details on Person UniProt:Q9H293 IL25
| Class:Id | ReferenceGeneProduct:56938 |
|---|---|
| _chainChangeLog | signal peptide:1-32 added on Sat February 7 2015;chain:33-177 added on Sat February 7 2015 |
| _displayName | UniProt:Q9H293 IL25 |
| _timestamp | 2026-02-20 22:33:23 |
| chain | signal peptide:1-32 chain:33-177 |
| checksum | 52D895710CD59871 |
| comment | FUNCTION Cytokine produced by various cells such as eosinophils, T-helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production (PubMed:15860795, PubMed:25821217). Promotes and augments T-helper type 2 responses locally or systemically (PubMed:25821217). Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction (By similarity). In turn, stimulates the JAK2-STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13 (PubMed:25821217). Also induces the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways (PubMed:15860795). Inhibits the differentiation of T-helper (Th17) cells via the production of IL4, IL5 and IL13 (PubMed:11754819).INTERACTION Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.SIMILARITY Belongs to the IL-17 family.ONLINE INFORMATION Interleukin-17 entry |
| description | recommendedName: Interleukin-25 shortName: IL-25 alternativeName: Interleukin-17E shortName: IL-17E |
| geneName | IL25 IL17E UNQ3120/PRO10272 |
| identifier | Q9H293 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytokine Direct protein sequencing Disulfide bond Glycoprotein Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | IL25 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996646] ENSEMBL:ENSG00000166090 IL25 [Homo sapiens] |
| secondaryIdentifier | IL25_HUMAN Q2M3F0 Q8IZV3 Q8WXB0 |
| sequenceLength | 177 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:148617] UniProt:Q9H293-2 IL25 [Homo sapiens] [ReferenceIsoform:414190] UniProt:Q9H293-1 IL25 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:447101] IL25 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8951059] IL25 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9H293 IL25 (56938)
