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Details on Person NAALADases hydrolyse NAAG

Class:Id	Reaction:5693783
_displayName	NAALADases hydrolyse NAAG
_doRelease	TRUE
_timestamp	2024-11-08 15:22:54
authored	[InstanceEdit:5693803] Jassal, Bijay, 2015-05-18
catalystActivity	[CatalystActivity:5693774] dipeptidase activity of NAALADases [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5693765] Jassal, Bijay, 2015-05-18
crossReference	[DatabaseIdentifier:9925785] RHEA:68357
edited	[InstanceEdit:5693803] Jassal, Bijay, 2015-05-18
input	[SimpleEntity:5693762] NAAG [cytosol] [SimpleEntity:29356] H2O [cytosol]
internalReviewed	[InstanceEdit:9926227] D'Eustachio, Peter, 2024-10-31
isChimeric	FALSE
literatureReference	[LiteratureReference:5693775] Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer [LiteratureReference:5693764] The role of glutamate signaling in pain processes and its regulation by GCP II inhibition [LiteratureReference:480782] Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity [LiteratureReference:6787347] Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III [LiteratureReference:6787345] Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene
modified	[InstanceEdit:6785238] Jassal, Bijay, 2015-06-26 [InstanceEdit:6785240] Jassal, Bijay, 2015-06-26 [InstanceEdit:6787348] Jassal, Bijay, 2015-07-13 [InstanceEdit:6792911] Jassal, Bijay, 2015-08-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25 [InstanceEdit:9926226] D'Eustachio, Peter, 2024-10-31 [InstanceEdit:9927661] D'Eustachio, Peter, 2024-11-08
name	NAALADases hydrolyse NAAG H2O + N-acetyl-L-aspartyl-L-glutamate => L-glutamate + N-acetyl-L-aspartate
output	[SimpleEntity:5693772] NAASP [cytosol] [SimpleEntity:29404] L-Glu [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26 [InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796837] R-HSA-5693783.3
structureModified	[InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25
summation	[Summation:5693776] Excessive glutamate has been implicated in neurodegenerative...
(hasEvent)	[Pathway:8963693] Aspartate and asparagine metabolism [Homo sapiens]
(precedingEvent)	[Reaction:70581] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] [Homo sapiens] [Reaction:372448] SLC25A12,13 exchange L-Glu and L-Asp [Homo sapiens] [Reaction:5691507] ASPA deacetylates NAASP to acetate and L-aspartate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9928525] Update Tracker - [Reaction:5693783] NAALADases hydrolyse NAAG - v91:[modifyText, removeInput] [_UpdateTracker:9939651] Update Tracker - [Reaction:5693783] NAALADases hydrolyse NAAG - v92:[modifyText]
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