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Details on Person Initial resection of double-strand break ends
Class:Id Reaction:5693608 _displayName Initial resection of double-strand break ends _doRelease TRUE _timestamp 2015-09-04 20:34:46 authored [InstanceEdit:75141] Matthews, L, 2003-08-11 05:43:00 catalystActivity [CatalystActivity:5684133] DNA endonuclease activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-BRCA1-C complex [nucleoplasm] compartment [Compartment:7660] nucleoplasm created [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 edited [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 figure [Figure:83623] /figures/HRR_resect.jpg goBiologicalProcess [GO_BiologicalProcess:25121] DNA double-strand break processing input [Complex:5684107] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-BRCA1-C complex [nucleoplasm] [Homo sapiens] [SimpleEntity:113518] H2O [nucleoplasm] literatureReference [LiteratureReference:5684117] CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle [LiteratureReference:913336] Human CtIP promotes DNA end resection [LiteratureReference:75196] Homologous recombinational repair of DNA ensures mammalian chromosome stability [LiteratureReference:83624] Polarity of human replication protein A binding to DNA. [LiteratureReference:83625] Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. [LiteratureReference:111376] The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. modified [InstanceEdit:5693622] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6784748] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Initial resection of double-strand break ends output [SimpleEntity:30555] dNTP [nucleoplasm] [Complex:5685983] 3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] [Homo sapiens] precedingEvent
releaseDate 2003-11-03 reviewed [InstanceEdit:5693179] Borowiec, James A, 2015-06-12 reviewStatus [ReviewStatus:9821382] five stars revised [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:6796826] R-HSA-5693608.2 summation [Summation:5693535] In order for repair of the DNA double-strand breaks to occur... (hasEvent) [Pathway:5693607] Processing of DNA double-strand break ends [Homo sapiens] (precedingEvent) [Reaction:5685985] EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment [Homo sapiens] [NegativePrecedingEvent:9766964] Abundant Molecules: Initial resection of double-strand break ends (replacementInstances) [_Deleted:6793174] Deletion of instance: 83897
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