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Details on Person Association of Ku heterodimer with ends of DNA double-strand break

Class:Id	Reaction:5693599
_displayName	Association of Ku heterodimer with ends of DNA double-strand break
_doRelease	TRUE
_timestamp	2022-01-24 13:46:02
authored	[InstanceEdit:75904] Matthews, L, 2003-09-07 08:47:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:5686692] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] [Homo sapiens] [Complex:75905] XRCC5:XRCC6 [nucleoplasm] [Homo sapiens] [Complex:75905] XRCC5:XRCC6 [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:76260] Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. [LiteratureReference:76262] Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids. [LiteratureReference:76314] Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. [LiteratureReference:76287] Regulation and mechanisms of mammalian double-strand break repair. [Book:76534] 9781555810887 Walker, Graham C DNA Repair and Mutagenesis [LiteratureReference:5686698] Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex
modified	[InstanceEdit:5693622] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6784748] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6784817] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9762400] Orlic-Milacic, Marija, 2022-01-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Association of Ku heterodimer with ends of DNA double-strand break
output	[Complex:5682542] UBE2N:UBE2V2 [nucleoplasm] [Homo sapiens] [Complex:75906] XRCC5:XRCC6:DNA DSBs [nucleoplasm] [Homo sapiens] [Complex:5682540] RNF8:Zn2+ [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:480742] RIF1 [nucleoplasm] [Homo sapiens] [Complex:5682166] p-MRN [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3321979] KAT5 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5683418] p-S25,S1778-TP53BP1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2993789] PIAS4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4551605] RNF168 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5682984] p-S102-WHSC1 [nucleoplasm] [Homo sapiens] [Complex:5682525] p-5T-MDC1 [nucleoplasm] [Homo sapiens] [Complex:5682998] K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5619395] PAXIP1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5693527] p-S1981,Ac-K3016-ATM [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5682615] p-T4827,SUMO1-HERC2 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5686685] RIF1 and PAX1IP bind TP53BP1 at DNA DSBs [Homo sapiens] [Reaction:5683801] CHEK2 phosphorylates BRCA1 [Homo sapiens]
releaseDate	2003-11-03
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796823] R-HSA-5693599.3
summation	[Summation:5693572] Ionizing radiation (IR) induces single-strand breaks, i.e., ...
(hasEvent)	[Pathway:5693571] Nonhomologous End-Joining (NHEJ) [Homo sapiens]
(precedingEvent)	[Reaction:5693615] Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis [Homo sapiens]
(replacementInstances)	[_Deleted:6793029] Deletion of instance: 75917
(updatedInstance)	[_UpdateTracker:9775160] Update Tracker - [Reaction:5693599] Association of Ku heterodimer with ends of DNA double-strand break - v80:[add_removeOutput]
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