Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person RAD52 can simultaneously interact with RAD51 and RPA. The in...
| Class:Id | Summation:5693585 |
|---|---|
| _displayName | RAD52 can simultaneously interact with RAD51 and RPA. The in... |
| _timestamp | 2015-06-22 14:44:52 |
| created | [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 |
| modified | [InstanceEdit:5693622] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6784748] Orlic-Milacic, Marija, 2015-06-22 |
| text | RAD52 can simultaneously interact with RAD51 and RPA. The interaction with RAD51 may inhibit the formation of the invading RAD51 filament by sequestering RAD51 from RPA, thus promoting single strand annealing (SSA) instead of homologous recombination (Chen et al. 1999, Stark et al. 2004, Singleton et al. 2002, Mansour et al. 2008). The interaction of RAD51 and RAD52 is promoted by ABL1-mediated phosphorylation of both RAD51 and RAD52 (Chen et al. 1999, Van Dyck et al. 1999), which also increases RAD52 affinity for DNA (Honda et al. 2011). |
| (summation) | [Reaction:5693564] Association of RAD51 with RAD52:DNA double-strand break ends [Homo sapiens] |
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No pathways have been reviewed or authored by RAD52 can simultaneously interact with RAD51 and RPA. The in... (5693585)
