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Details on Person Association of RAD52 with the RPA complex at resected DNA DSBs

Class:Id	Reaction:5693580
_displayName	Association of RAD52 with the RPA complex at resected DNA DSBs
_doRelease	TRUE
_timestamp	2022-02-24 17:10:06
authored	[InstanceEdit:73965] Thompson, L, 2003-07-14 15:03:24
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:5685162] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Homo sapiens] [Complex:5686589] p-Y104-RAD52 heptamer [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:83611] Precise binding of single-stranded DNA termini by human RAD52 protein. [LiteratureReference:5686535] Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding [LiteratureReference:5686518] BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair [LiteratureReference:5686520] Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation [LiteratureReference:5686514] Physical interaction between human RAD52 and RPA is required for homologous recombination in mammalian cells [LiteratureReference:5686516] WRN interacts physically and functionally with the recombination mediator protein RAD52 [LiteratureReference:5686540] Analysis of the human replication protein A:Rad52 complex: evidence for crosstalk between RPA32, RPA70, Rad52 and DNA
modified	[InstanceEdit:5693622] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:5693974] Orlic-Milacic, Marija, 2015-05-19 [InstanceEdit:6784748] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6784817] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9766947] Orlic-Milacic, Marija, 2022-02-24 [InstanceEdit:9766963] Orlic-Milacic, Marija, 2022-02-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Association of RAD52 with the RPA complex at resected DNA DSBs
negativePrecedingEvent	[NegativePrecedingEvent:9766942] Futile Cycle: Activation of CHEK1 at resected DNA DSBs [NegativePrecedingEvent:9766955] Futile Cycle: ERCC1:XPF cleaves flaps generated by SSA
output	[Complex:5693547] p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5685156] ATR phosphorylates RPA2 [Homo sapiens] [Reaction:5685011] ATR activation at DNA DSBs [Homo sapiens] [Reaction:5686587] ABL1 phosphorylates RAD52 [Homo sapiens] [Reaction:5686578] Activated ATM phosphorylates ABL1 [Homo sapiens] [Reaction:75998] Formation of RAD52 heptameric ring structure complexes [Homo sapiens]
releaseDate	2003-11-03
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796817] R-HSA-5693580.3
summation	[Summation:5693559] RAD52 heptamers bind 3' overhanging ssDNA at resected DNA do...
(hasEvent)	[Pathway:5685938] HDR through Single Strand Annealing (SSA) [Homo sapiens]
(precedingEvent)	[Reaction:5693564] Association of RAD51 with RAD52:DNA double-strand break ends [Homo sapiens]
(replacementInstances)	[_Deleted:6793039] Deletion of instance: 83644 [_Deleted:6793041] Deletion of instance: 109779
(updatedInstance)	[_UpdateTracker:9775509] Update Tracker - [Reaction:5693580] Association of RAD52 with the RPA complex at resected DNA DSBs - v78:[modifyText]
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