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Details on Person TDP1 and TDP2 process unligatable DSB ends

Class:Id	Reaction:5693578
_displayName	TDP1 and TDP2 process unligatable DSB ends
_doRelease	TRUE
_timestamp	2015-09-04 20:34:36
authored	[InstanceEdit:73967] Lees-Miller, S, 2003-07-14 15:03:25
catalystActivity	[CatalystActivity:5693569] phosphoric diester hydrolase activity of (TDP1,TDP2) [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:5693546] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Trimmed DNA DSB ends [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:175594] Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1 [LiteratureReference:5687384] TDP1 promotes assembly of non-homologous end joining protein complexes on DNA [LiteratureReference:5687387] Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks [LiteratureReference:5687398] TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo [LiteratureReference:5687401] Processing of damaged DNA ends for double-strand break repair in mammalian cells
modified	[InstanceEdit:5693622] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6784748] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6784817] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TDP1 and TDP2 process unligatable DSB ends
output	[Complex:5687345] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Ligatable DNA DSB ends [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5693533] DCLRE1C (ARTEMIS) processes DNA DSB ends [Homo sapiens] [Reaction:5687183] PRKDC phosphorylates DCLRE1C at DNA DSBs [Homo sapiens]
releaseDate	2003-11-03
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796816] R-HSA-5693578.2
summation	[Summation:5693562] Free radical-induced DNA double strand breaks (DSBs) frequen...
(hasEvent)	[Pathway:5693571] Nonhomologous End-Joining (NHEJ) [Homo sapiens]
(precedingEvent)	[Reaction:5693574] XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ [Homo sapiens]
(replacementInstances)	[_Deleted:6793168] Deletion of instance: 175588 [_Deleted:6793404] Deletion of instance: 75924
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No pathways have been reviewed or authored by TDP1 and TDP2 process unligatable DSB ends (5693578)